Data/hora: 05/06/2024 15:21:47

Provedor de dados: | 80
País: | Brazil
Título: | Cardiac evaluation after experimental intoxication by Amorimia rigida (Malpighiaceae) extracts in rabbits
Autores: | Borboleta,LR; Silva,EF; Oliveira,MS; Michel,AFRM; Ferraz,VP; Leite,RC; Melo,MM.
Data: | 2012-01-01
Ano: | 2012
Palavras-chave: | Toxic plant; Amorimia rigida; Cardiac muscle profile; Electrocardiography; Echocardiography; Rabbit.
Resumo: | Clinical and laboratory changes were evaluated in rabbits after intoxication by Amorimia rigida, a plant that causes sudden death. Nine New Zealand male rabbits, averaging 3.54 kg, were categorized into three groups (n = 3) and received, for eight consecutive days, the equivalent of 30 g/kg dry matter of A. rigida water-soluble (SG) and water-insoluble (IG) extracts via nasoesophageal route. The control group received water. There were no alterations in creatine kinase enzyme (CK), CK myocardial fraction (CKMB) or troponine I (cTnI). None of the animals had clinical or electrocardiographic (conventional and Holter) alterations. There were progressive decreases in the left ventricular ejection fraction and systolic fractional shortening. Doppler echocardiography alterations suggested a systolic dysfunction in the SG and IG groups and diastolic dysfunction in IG group. It was concluded that the soluble and insoluble extracts of A. rigida cause deficit of cardiac function.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000300007
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1590/S1678-91992012000300007
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.18 n.3 2012
Fonte: | info:eu-repo/semantics/openAccess