Data/hora: 01/06/2024 04:58:25

Provedor de dados: | 80
País: | Brazil
Título: | Measurement of IL-10 serum levels in BALB/c mice treated with beta-1,3 polyglucose or sulfadiazine and acutely infected by Toxoplasma gondii
Autores: | Picka,M. C. M.; Calvi,S. A.; Lima,C. R. G.; Santos,I. A. T.; Marcondes-Machado,J.
Data: | 2005-12-01
Ano: | 2005
Palavras-chave: | Toxoplasma gondii; Interleukin-10; Glucan; Immune response; Sulfadiazine.
Resumo: | Acute infection by Toxoplasma gondii leads to suppression of cell-mediated immunity, facilitating chronic infection. One of the causes of immunosuppression is Interleukin-10 (IL-10) production. Glucan is used to stimulate phagocytosis. Our objective was to study IL-10 induction in male BALB/c mice with acute T. gondii BTU-2 strain infection, glucan immunostimulation, and sulfadiazine treatment. Animals were distributed into 7 groups: G1: infected with T. gondii; G2: infected with T. gondii and treated with sulfadiazine; G3: infected with T. gondii and immunostimulated with glucan; G4: infected with T. gondii, immunostimulated with glucan, and treated with sulfadiazine; G5: imunostimulated with glucan; G6: treated with saline; and G7: treated with sulfadiazine. IL-10 levels were determined by ELISA; the highest levels were found in G2, G3 and G4, and the lowest in G1 (p&lt;0.001). Groups G1 to G5 and G7 had substantially higher levels than G6 (p&lt;0.001). In this study, the highest IL-10 levels were found in groups treated with glucan.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000400012
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1590/S1678-91992005000400012
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.11 n.4 2005
Fonte: | info:eu-repo/semantics/openAccess