Data/hora: 06/06/2024 05:35:31

Provedor de dados: | 80
País: | Brazil
Título: | DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
Autores: | Barbosa,Adriana Sierra Assencio Almeida; Oliveira,Larissa Ragozo Cardoso de; Tavares,Francilene Capel; Lima,Carlos Roberto Gonçalves de; Diório,Suzana Madeira; Calvi,Sueli Aparecida; Vilani-Moreno,Fátima Regina; Pereira,Paulo Câmara Marques.
Data: | 2015-01-01
Ano: | 2015
Palavras-chave: | Jorge Lobo’ disease; Lacazia loboi; Malnutrition; Mice; Genotoxicity; Comet assay.
Resumo: | AbstractBackground Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100317
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1186/s40409-015-0006-y
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.21 2015
Fonte: | info:eu-repo/semantics/openAccess