Data/hora: 05/06/2024 14:13:18

Provedor de dados: | 80
País: | Brazil
Título: | Effect of propolis extract on guines pig lung mast cell
Autores: | Orsi,R. O.; Sforcin,J. M.; Funari,S. R. C.; Gomes,J. C.
Data: | 2005-03-01
Ano: | 2005
Palavras-chave: | Mast cells; Allergy; Histamine; Propolis.
Resumo: | The direct effect of ethanolic extract of propolis on guinea pig lung cell suspension containing mast cells, as well as its influence on the histamine release induced by antigen (ovoalbumin 10 mug/ml) and ionophore A 23187 (3 muM) were investigated. Propolis ethanolic extract (300 mug/ml) increased the histamine release in guinea pig lung suspension containing mast cells by a cytotoxic effect. Lower concentrations of propolis had no effect on histamine release. Our results demonstrated that propolis (3, 10, 30, and 100 mug/ml) shows no significant effect on the histamine release induced by ionophore and antigen. Based on these results, we suggest that propolis could directly activate mast cells, promoting inflammatory mediators release by cytotoxic mechanisms, what could be related to allergic processes in propolis sensitive people.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000100009
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1590/S1678-91992005000100009
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.11 n.1 2005
Fonte: | info:eu-repo/semantics/openAccess