Data/hora: 10/06/2024 08:22:31

Provedor de dados: 	80	
País: 	Brazil	
Título: 	Behavioral alterations induced by repeated saxitoxin exposure in drinking water	
Autores: 	Diehl,Felipe; Ramos,Patricia Baptista; Santos,Juliane Marques dos; Barros,Daniela Martí; Yunes,João Sarkis.	
Data: 	2016-01-01	
Ano: 	2016	
Palavras-chave: 	Saxitoxin; Drinking water; Behavior; Aversive memory; Spatial memory; Rats.	
Resumo: 	Abstract  Background  Blooms of the saxitoxin-producing cyanobacterium Cylindrospermopsis raciborskii have been contaminating drinking water reservoirs in Brazil for many years. Although acute effects of saxitoxin intoxication are well known, chronic deleterious outcomes caused by repeated saxitoxin exposure still require further investigation. The aim of the present work is to investigate the effects of consumption of drinking water contaminated with C. raciborskii for 30 days on learning and memory processes in rats.  Methods  The effects of saxitoxin (3 or 9 μg/L STX equivalents) or cyanobacteria on behavior was determined using the open field habituation task, elevated plus maze anxiety model task, inhibitory avoidance task, and referential Morris water maze task.  Results  No effects of saxitoxin consumption was observed on anxiety and motor exploratory parameters in the elevated plus maze and open field habituation tasks, respectively. However, groups treated with 9 μg/L STX equivalents displayed a decreased memory performance in the inhibitory avoidance and Morris water maze tasks.  Conclusions  These results suggest an amnesic effect of saxitoxin on aversive and spatial memories.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100314	
Editor: 	Centro de Estudos de Venenos e Animais Peçonhentos	
Relação: 	10.1186/s40409-016-0072-9	
Formato: 	text/html	
Fonte: 	Journal of Venomous Animals and Toxins including Tropical Diseases  v.22 2016	
Fonte: 	info:eu-repo/semantics/openAccess