Data/hora: 01/06/2024 07:28:21

Provedor de dados: 	80	
País: 	Brazil	
Título: 	Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity	
Autores: 	Oliveira,Guilherme Honda de; Cerni,Felipe Augusto; Cardoso,Iara Aimê; Arantes,Eliane Candiani; Pucca,Manuela Berto.	
Data: 	2016-01-01	
Ano: 	2016	
Palavras-chave: 	Tityus serrulatus; Diabetes mellitus; Scorpion venom; NOD mice; Glycemia.	
Resumo: 	Abstract  Background  In Brazil, accidents with venomous animals are considered a public health problem. Tityus serrulatus (Ts), popularly known as the yellow scorpion, is most frequently responsible for the severe accidents in the country. Ts envenoming can cause several signs and symptoms classified according to their clinical manifestations as mild, moderate or severe. Furthermore, the victims usually present biochemical alterations, including hyperglycemia. Nevertheless, Ts envenoming and its induced hyperglycemia were never studied or documented in a patient with diabetes mellitus (DM). Therefore, this is the first study to evaluate the glycemia during Ts envenoming using a diabetic animal model (NOD, non-obese diabetic).  Methods  Female mice (BALB/c or NOD) were challenged with a non-lethal dose of Ts venom. Blood glucose level was measured (tail blood using a glucose meter) over a 24-h period. The total glycosylated hemoglobin (HbA1c) levels were measured 30 days after Ts venom injection. Moreover, the insulin levels were analyzed at the glycemia peak.  Results  The results demonstrated that the envenomed NOD animals presented a significant increase of glycemia, glycosylated hemoglobin (HbA1c) and insulin levels compared to the envenomed BALB/c control group, corroborating that DM victims present great risk of developing severe envenoming. Moreover, the envenomed NOD animals presented highest risk of death and sequelae.  Conclusions  This study demonstrated that the diabetic victims stung by Ts scorpion should be always considered a risk group for scorpion envenoming severity.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100319	
Editor: 	Centro de Estudos de Venenos e Animais Peçonhentos	
Relação: 	10.1186/s40409-016-0081-8	
Formato: 	text/html	
Fonte: 	Journal of Venomous Animals and Toxins including Tropical Diseases  v.22 2016	
Fonte: 	info:eu-repo/semantics/openAccess