Data/hora: 01/06/2024 14:03:04

Provedor de dados: 	80	
País: 	Brazil	
Título: 	Histological and biochemical effects induced by sublethal doses of Bothrops jararacussu venom in mice	
Autores: 	Zeni,A. L. B.; Becker,A.; Krug,M.; Albuquerque,C. A. C.	
Data: 	2007-01-01	
Ano: 	2007	
Palavras-chave: 	Bothrops jararacussu; Snake venoms; Sublethal doses; In vivo studies; Biochemical parameters; Histopathological alterations.	
Resumo: 	Snake venom is characterized by hemorrhagic, coagulant, proteolytic and myotoxic activities which in Bothrops jaracussu venom are related to intraspecific variations. In the present study, female Swiss mice were divided into two groups: treated with 25µg or 50µg venom. These were subdivided into three groups of six animals each, according to blood collection: 2, 4 or 24h after venom injection. Animals were anesthetized using diethyl-ether inhalation and 1ml of blood was collected by heart puncture. Then, the following organs were removed: spleen, skeletal muscle, kidneys, liver and lungs; histological sections were obtained and stained with hematoxylin-eosin (HE). The following biochemical parameters were analyzed: aspartate aminotransferase (AST/GOT), alanine aminotransferase (ALT/GPT), total lactate dehydrogenase (LDH), glucose, creatinine and urea levels, and total protein content. Results showed significant alterations in AST, LDH, glucose and urea levels, and total protein content, as well as important tissue alterations in the liver, kidneys and lungs. It could be concluded that, even using sublethal doses of venom, there were significant changes in almost all the tested biochemical parameters as well as tissue alterations in the kidneys and lungs.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000300009	
Editor: 	Centro de Estudos de Venenos e Animais Peçonhentos	
Relação: 	10.1590/S1678-91992007000300009	
Formato: 	text/html	
Fonte: 	Journal of Venomous Animals and Toxins including Tropical Diseases  v.13 n.3 2007	
Fonte: 	info:eu-repo/semantics/openAccess