Data/hora: 05/06/2024 14:04:29

Provedor de dados: | 89
País: | Brazil
Título: | Effects of E. Coli Infection on the Expressions of TGF-β/Smads Signaling Pathway in Broiler Intestine
Autores: | Juang,J; Yin,H; Zhang,C; Wang,J.
Data: | 2020-01-01
Ano: | 2020
Palavras-chave: | TGF-β/Smads; Intestinal lesion; E. coli; Chicken.
Resumo: | ABSTRACT This experiment aimed to investigate whether Escherichia coli (E. coli) infection could affect the TGF-β/smads signaling pathway in the jejunal tissue of chickens. One-day-old Cobb 500 broilers were randomly divided into 2 groups and treated with intraperitoneal E. coli or broth injection. Clinical signs of the birds were assessed every day. Spleen and bursa of Fabricius of the birds, post-infection (pi), were collected to evaluate immune organ index. Jejunal tissues were collected to ascertain the expression of TGF-βs, TβRs, and Smads. The results showed that the infected birds had significantly higher index of the spleen (24hrs and 48hrs pi) compared with birds in the control group (p&lt;0.05). The relative gene expression of TGF-β4 increased (p&lt;0.05), while the expression of Smad7 down-regulated in the E. coli group (p&lt;0.01). There was no significant difference in TGF-β2, TGF-β3, TβR I, TβR II, Smad2, Smad3 expression (p&gt;0.05). In conclusion, TGF-β/Smad signaling pathway was associated with the immune response of broilers in E. coli infection and TGF-β4 was the main subtype interacting with E. coli infection.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2020000100311
Editor: | Fundação APINCO de Ciência e Tecnologia Avícolas
Relação: | 10.1590/1806-9061-2019-1101
Formato: | text/html
Fonte: | Brazilian Journal of Poultry Science  v.22 n.1 2020
Fonte: | info:eu-repo/semantics/openAccess