Data/hora: 01/06/2024 10:35:56

Provedor de dados: | 98
País: | Cuba
Título: | Achyrocline satureioides (Lam.) DC. (marcela) reduces brain damage in permanent focal ischemia in rats
Autores: | Rivera Megret,Felicia; Tejera Correa,Dario; Abin Carriquiri,Juan Andrés; Prunell dos Santos,Giselle; Martínez Busi,Marcela; Dajas Méndez,Federico.
Data: | 2013-09-01
Ano: | 2013
Palavras-chave: | Achyroclines satureioides; Quercetin; Permanent focal ischemia.
Resumo: | Introduction: Achyrocline satureioides is a plant which has been widely used in popular medicine and experimental studies confirm its antioxidant and anti-inflammatory effects, attributable to the presence of flavonoids, mainly quercetin. Objectives: to evaluate the neuroprotective effects of a chronic oral pre-administration to rats with an Achyrocline satureioides decoction (2 %). Methods: for decoction, dried flowers of Achyrocline satureioides were used. The consumption of food and AS decoction/water of the rats was evaluated daily and weight gain weekly; quercetin content in the decoction and in the plasma of the rats was evaluated by high performance liquid chromatography. The cerebral damage was assessed with a tetrazolium salt (TTC) and a behavioral test was performed previously. Nissl staining and Fluoro-Jade histochemistry were used. Results: the pre-treatment with Achyrocline satureioides in all groups reverted the functional deficit and, during 21 days, the infarction volume also decreased significantly. Nissl staining showed a higher percentage of preserved neuronal population and the Fluoro-Jade showed a decreased of the neurons in degeneration. Conclusions: the quercetin levels in the decoction and plasma of rats could explain the preventive benefits of Achyrocline satureioides due to the antioxidant and anti-inflammatory properties described for this flavonoid.
Tipo: | Journal article
Idioma: | Inglês
Identificador: | http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962013000300011
Editor: | ECIMED
Formato: | text/html
Fonte: | Revista Cubana de Plantas Medicinales  v.18 n.3 2013