Sabiia Seb
PortuguêsEspañolEnglish
Embrapa
        Busca avançada

Botão Atualizar


Botão Atualizar

Registro completo
Provedor de dados:  Repositório Alice
País:  Brazil
Título:  Initial analysis of copy number variations in canchim beef cattle with extreme phenotypes for ribeye area.
Autores:  GIACHETTO, P. F.
PEREIRA, F. C. P.
MOKRY, F. B.
HIGA, R. H.
MUDADU, M. A.
SILVA, M. V.
NICIURA, S. C. M.
CARDOSO, F. F.
ALENCAR, M. M.
MEIRELLES, S. L. C.
LIMA, A. O.
REGITANO, L. C. A.
Data:  2014-01-02
Ano:  2013
Palavras-chave:  Variação genética
Polimorfismo de nucleotídeo único
Bioinformática
Copy number variations
Genetic variation
Single nucleotide polymorphisms
Bioinformatics
Resumo:  Genomic structural variation, in the form of large-scale insertions and deletions, as well as inversions and translocations, are referred to as copy number variations (CNVs). Compared to single nucleotide polymorphisms (SNPs), CNVs have potentially greater effects on gene structure, dosage and regulation, being an important source of phenotypic variation. In humans, CNVs are widespread in the genome and have been shown to be associated with complex traits. In livestock species, the characterization of this genetic variation is an important step toward linking genes or genomic regions with phenotypic traits of economic importance. Studies in cattle have revealed some CNVs associated with differences in host parasite resistance and breed-specific differences in adaptation, health, and production traits. We report initial data from an analysis of CNVs in Canchim, a synthetic cattle (5/8 Charolais + 3/8 Zebu) that has been selected for meat production in Brazil. Using the PennCNV software and data from 192 Canchim DNA samples with extreme phenotypes for ribeye area, genotyped with Illumina BovineHD BeadChip, a total of 6,985 CNVs were detected. The regions ranged from 20,012bp to 4,157,122bp, with mean and median of 140,484bp and 81,303bp, respectively. Copy number gains (62.09%) were found to be more common than deletions. Gene content of discovered CNVs and functional enrichment analysis are being assessed using Ensembl genes and cattle RefSeq databases, and PANTHER classification system, respectively. We expect to use these findings in genome wide association studies to better understand the genetic variation underlying meat quality in beef cattle.

2013

Pôster P0572.
Tipo:  Resumo em anais de congresso (ALICE)
Idioma:  Inglês
Identificador:  17699

http://www.alice.cnptia.embrapa.br/handle/doc/974748

http://ainfo.cnptia.embrapa.br/digital/bitstream/item/94588/1/P0572.odt
Editor:  In: INTERNATIONAL PLANT & ANIMAL GENOME, 21., 2013, San Diego. [Abstracts]... [S.l.: s.n.], 2013.
Relação:  Embrapa Informática Agropecuária - Resumo em anais de congresso (ALICE)
Formato:  Não paginado.
Fechar
 

Empresa Brasileira de Pesquisa Agropecuária - Embrapa
Todos os direitos reservados, conforme Lei n° 9.610
Política de Privacidade
Área restrita

Embrapa
Parque Estação Biológica - PqEB s/n°
Brasília, DF - Brasil - CEP 70770-901
Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco

Valid HTML 4.01 Transitional