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Provedor de dados:  Repositório Alice
País:  Brazil
Título:  Bioprospection of Petit Verdot grape pomace as a source of anti-inflammatory compounds.
Autores:  DENNY, C.
LAZARINI, J. G.
FRANCHIN, M.
MELO, P. S.
PEREIRA, G. E.
MASSARIOLI, A. P.
MORENO, I. A. M.
PASCHOAL, J. A. R.
ALENCAR, S. M.
ROSALEN, P. L.
Data:  2014-07-22
Ano:  2014
Palavras-chave:  Subprodutos
Citocinas
Petit Verdot
Bagaço de uva
Vitis vinifera
Uva
Antiinflamatorio
Composto fenolico
Anti-inflammatory activity
Phenolic compounds
Grapes
Resumo:  The aim of this study was to evaluate the anti-inflammatory activity of Petit Verdot Extract and hexane, chloroform and ethyl acetate fractions obtained from grape pomace, in addition to identifying active compounds. The PVE and EAF reduced significantly paw edema and neutrophil migration when compared with control groups. The PVE reduced levels of TNF-α and IL1-β in the peritoneal fluid, whereas the EAF did not reduce cytokines significantly. Two hydroxybenzoic acids, two proanthocyanidins, three flavan-3-ol monomers and three anthocyanins were identified in the PVE and EAF by LC-MS/MS. The stilbene transresveratrol was identified only in the EAF. The phenolic compounds were quantified using HPLC-DAD analysis, except for the stilbenes, which were not sensible for the detection by the method. Since PVE and EAF showed significantly anti-inflammatory effects and high concentration of phenolic compounds, we concluded that Petit Verdot pomace could be an interesting source of anti-inflammatory bioactives.

2014
Tipo:  Artigo em periódico indexado (ALICE)
Idioma:  Inglês
Identificador:  1756-4646

52931

http://www.alice.cnptia.embrapa.br/handle/doc/991125

http://ainfo.cnptia.embrapa.br/digital/bitstream/item/105261/1/Giuliano-2014.pdf

10.1016/j.jff.2014.03.016
Editor:  Journal of Functional Foods, v. 8, p. 292-300, 2014.
Relação:  Embrapa Semiárido - Artigo em periódico indexado (ALICE)
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