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Provedor de dados:  Nature Precedings
País:  United Kingdom
Título:  11-amino-5-N-methyl-7-fluorine- quindoline derivatives: The Potential Anti-angiogenic Agents Targeting G-quadruplex Structure in Vascular Endothelial Cell Growth Factor
Autores:  Tian-miao Ou
Yu-jing Lu
Xiao-dong Wang
Zeng-yun An
Yan-ping Li
Zhi-shu Huang
Lian-quan Gu
Data:  2008-06-04
Ano:  2008
Palavras-chave:  Cancer
Resumo:  Vascular endothelial growth factor (VEGF), a pluripotent cytokine and angiogenic growth factor, plays crucial roles in embryonic development and tumour progression, and is over-expressed in many types of cancer and generally associated with tumour progression and survival rate. The polypurine/polypyrimide sequence located upstream (-89 to -43) of the promoter region of the human VEGF gene that can form specific G-quadruplex structures and raise the possibility for transcriptional control of the VEGF gene by G-quadruplex ligands. In the present study, we investigated the interaction between the 5-N-methyl-7-fluorine-quindoline derivatives (11-amino-5-N-methyl-7-fluorine- quindoline derivatives) and the G-rich sequence in VEGF's promoter and the subsequent effects on the biological functions of VEGF. We found the strong interaction between the 5-N-methyl-7-fluorine-quindoline derivatives and the G-rich DNA of VEGF, and this interaction might significantly influence the biological functions of VEGF, including the transcription and expression of VEGF, cell proliferation and apoptosis, and the stimulation of angiogenesis in chick embryo.
Tipo:  Manuscript
Fonte:  Nature Precedings
Direitos:  Creative Commons Attribution 3.0 License

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