| Registro completo |
| Provedor de dados: |
IPB - Escola Superior Agrária
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| País: |
Portugal
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| Título: |
Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure–activity evaluation study
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| Autores: |
Ferreira, Isabel C.F.R.
Calhelha, Ricardo C.
Estevinho, Leticia M.
Queiroz, Maria João R.P.
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| Data: |
2008-09-12
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| Ano: |
2004
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| Palavras-chave: |
Diarylamines
Antimicrobial activity
SAR
Benzothiophenes
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| Resumo: |
Gram positive (Bacillus cereus, B. subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[ b]thiophene series bearing different substituents, synthesized by us using the palladium-catalyzed C–N coupling methodology. The minimal inhibitory concentration (MIC) and structure–activity relationships (SARs) were evaluated.
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| Tipo: |
Article
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| Idioma: |
Inglês
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| Identificador: |
Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 14:23 (2004) p. 5831-5833
0960-894X
http://hdl.handle.net/10198/821
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| Editor: |
Elsevier
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| Direitos: |
open access
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