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Provedor de dados:  Inra
País:  France
Título:  The FeFe hydrogenase of Nyctotherus ovalis has a chimeric origin
Autores:  Boxma, B.
Ricard, G.
van Hoek, A. H.
Severing, E.
Moon-van der Staay, S.Y.
van der Staay, G.W.M.
van Alen, T.A.
de Graaf, R.M.
Cremers, G.
Kwantes, M.
McEwan, N.R.
Newbold, C.J.
Jouany, J.P.
Michalowski, T.
Pristas, P.
Huynen, M.A.
Hackstein, J.H.P.
Data:  2007
Ano:  2007
Palavras-chave:  MITOCHONDRIE
CILIE
HYDROGENASE MULTIPLE SEQUENCE ALIGNMENT
COMPLEX-I
PHYLOGENETIC ANALYSIS
EUKARYOTIC EVOLUTION
IRON HYDROGENASES
LIFE-STYLE
HYDROGENOSOMES
MITOCHONDRIA
PROTEIN
MODELS
Resumo:  Background: The hydrogenosomes of the anaerobic ciliate Nyctotherus ovalis show how mitochondria can evolve into hydrogenosomes because they possess a mitochondrial genome and parts of an electron-transport chain on the one hand, and a hydrogenase on the other hand. The hydrogenase permits direct reoxidation of NADH because it consists of a [ FeFe] hydrogenase module that is fused to two modules, which are homologous to the 24 kDa and the 51 kDa subunits of a mitochondrial complex I.Results: The [ FeFe] hydrogenase belongs to a clade of hydrogenases that are different from well-known eukaryotic hydrogenases. The 24 kDa and the 51 kDa modules are most closely related to homologous modules that function in bacterial [ NiFe] hydrogenases. Paralogous, mitochondrial 24 kDa and 51 kDa modules function in the mitochondrial complex I in N. ovalis. The different hydrogenase modules have been fused to form a polyprotein that is targeted into the hydrogenosome.Conclusion: The hydrogenase and their associated modules have most likely been acquired by independent lateral gene transfer from different sources. This scenario for a concerted lateral gene transfer is in agreement with the evolution of the hydrogenosome from a genuine ciliate mitochondrion by evolutionary tinkering.
Tipo:  Journal Article
Idioma:  Inglês
Identificador:  http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2008786cfe28&uri=/notices/prodinra1/2009/10/

http://www.prodinra.inra.fr/prodinra/pinra/data/2009/10/PROD2008786cfe2_20091028093124095.pdf
Formato:  application/pdf
Fonte:  BMC Evolutionary Biology. 2007, 7 : 230
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