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Provedor de dados:  Inra
País:  France
Título:  Multiple parasites mediate balancing selection at two MHC class II genes in the fossorial water vole: insights from multivariate analyses and population genetics
Autores:  Tollenaere, C.
Bryja, J.
Galan, M.
Cadet, P.
Deter, J.
Chaval, Y.
Berthier, K.
Ribas Salvador, A.
Voutilainen, L.
Laakkonens, J.
Cosson, J.F.
Charbonnel, N.
Data:  2008
Ano:  2008
Palavras-chave:  IMMUNOGENETIQUE
CO-INERTIE
GENES MHC
ANALYSE MULTIVARIEE CO-INERTIA
DQA AND DRB MHC GENES
IMMUNOGENETICS
MULTIVARIATE ANALYSIS
PARASITE-MEDIATED BALANCING SELECTION
Resumo:  We investigated the factors mediating selection acting on two MHC class II genes (DQA and DRB) in water vole (Arvicola scherman) natural populations in the French Jura Mountains. Population genetics showed significant homogeneity in allelic frequencies at the DQA1 locus as opposed to neutral markers (nine microsatellites), indicating balancing selection acting on this gene. Moreover, almost exhaustive screening for parasites, including gastrointestinal helminths, brain coccidia and antibodies against viruses responsible for zoonoses, was carried out. We applied a co-inertia approach to the genetic and parasitological data sets to avoid statistical problems related to multiple testing. Two alleles, Arte-DRB-11 and Arte-DRB-15, displayed antagonistic associations with the nematode Trichuris arvicolae, revealing the potential parasite-mediated selection acting on DRB locus. Selection mechanisms acting on the two MHC class II genes thus appeared different. Moreover, overdominance as balancing selection mechanism was showed highly unlikely in this system
Tipo:  Journal Article
Idioma:  Inglês
Identificador:  http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20091657fa4b&uri=/notices/prodinra1/2011/06/
Fonte:  Journal of Evolutionary Biology. 2008, 21 (5) : 1307–1320
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