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Provedor de dados:  Inra
País:  France
Título:  Identification of QTL with effects on intramuscular fat content and fatty acid composition in a Duroc x Large White cross
Autores:  Sanchez, M.P.
Iannuccelli, N.
Basso, B.
Bidanel, J.P.
Billon, Y.
Gandemer, G.
Gilbert, H.
Larzul, C.
Legault, C.
Riquet, J.
Milan, D.
Le Roy, P.
Data:  2007
Ano:  2007
Palavras-chave:  QUANTITATIVE TRAIT LOCI
FATTY ACID COMPOSITION
Resumo:  Background: Improving pork quality can be done by increasing intramuscular fat (IMF) content. This trait is influenced by quantitative trait loci (QTL) sought out in different pig populations. Considering the high IMF content observed in the Durocpig, it was appealing to determine whether favourable alleles at a major gene or QTL could be found. The detection wasperformed in an experimental F2 Duroc × Large White population first by segregation analysis, then by QTL mapping usingadditional molecular information.Results: Segregation analysis provided evidence for a major gene, with a recessive Duroc allele increasing IMF by 1.8% in Durochomozygous pigs. However, results depended on whether data were normalised or not. After Box-Cox transformation, likelihood ratio was indeed 12 times lower and no longer significant. The QTL detection results were partly consistent with the segregation analysis. Three QTL significant at the chromosome wide level were evidenced. Two QTL, located on chromosomes 13 and 15, showed a high IMF Duroc recessive allele with an overall effect slightly lower than that expected from segregation analysis (+0.4 g/100 g muscle). The third QTL was located on chromosome 1, with a dominant Large White allele inducing high IMF content (+0.5 g/100 g muscle). Additional QTL were detected for muscular fatty acid composition.Conclusion: The study presented results from two complementary approaches, a segregation analysis and a QTL detection,to seek out genes involved in the higher IMF content observed in the Duroc population. Discrepancies between both methods might be partially explained by the existence of at least two QTL with similar characteristics located on two different chromosomes for which different boars were heterozygous. The favourable and dominant allele detected in the Large Whitepopulation was unexpected. Obviously, in both populations, the favourable alleles inducing high IMF content were not fixed andimproving IMF by fixing favourable alleles using markers can then be applied both in Duroc and LW populations. With QTLaffecting fatty acid composition, combining an increase of IMF content enhancing monounsaturated fatty acid percentage wouldbe of great interest.
Tipo:  Journal Article
Idioma:  Inglês
Identificador:  http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2008399a868b&uri=/notices/prodinra1/2011/02/

http://www.prodinra.inra.fr/prodinra/pinra/data/2008/04/PROD2008399a868b_20080421123055060.pdf
Formato:  application/pdf
Fonte:  BMC Genetics. 2007, 8 : 55
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