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Provedor de dados:  Inra
País:  France
Título:  A first-generation microsatellite-based integrated genetic and cytogenetic map for the European rabbit ( Oryctolagus cuniculus) and localization of angora and albino
Autores:  Chantry-Darmon, C.
Urien, C.
De Rochambeau, H.
Allain, D.
PENA, B.
Hayes, H.
Grohs, C.
Cribiu, E.
Deretz, S.
Larzul, C.
Save, J.C.
Chardon, P.
Rogel-Gaillard, C.
Data:  2006
Ano:  2006
Palavras-chave:  ALBINO
ANGORA
CHROMOSOMES
CYTOGENETIC MAP
GENETIC MAP
LINKAGE
MICRO-SATELLITES
RABBIT
Resumo:  Although the European rabbit (Oryctolagus cuniculus) is used both in agronomics and inresearch, genomic resources for this species are still limited and no microsatellite-basedgenetic map has been reported. Our aim was to construct a rabbit genetic map with cytogeneticallymapped microsatellites so as to build an integrated genetic and cytogeneticmap. A reference population of 187 rabbits comprising eight three-generation families with10–25 offspring per family was produced. One hundred and ninety-four of 305 previouslyidentified microsatellites were included in this study. Of these, 158 were polymorphic withtwo to seven alleles. The map reported here comprises 111 markers, including 104 INRAmicrosatellites, five microsatellites from another source and two phenotypic markers (angoraand albino). Ninety markers were integrated into 20 linkage groups. The remaining 21microsatellites mapped to separate linkage groups, 19 with a precise cytogenetic positionand two with only a chromosomal assignment. The genetic map spans 2766.6 cM andcovers 20 rabbit chromosomes, excluding chromosomes 20, 21 and X. The density of thismap is limited, but we used it to verify the location of angora and albino on chromosomes15q and 1q, respectively, in agreement with previously published data. This first generationgenetic/cytogenetic map will help gene identification and quantitative trait loci mappingprojects in rabbit.
Tipo:  Journal Article
Idioma:  Inglês
Identificador:  http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2007e498c5d1&uri=/notices/prodinra1/2008/08/

http://www.prodinra.inra.fr/prodinra/pinra/data/2007/08/PROD2007e498c5d1_20070824121023128.pdf
Formato:  application/pdf
Fonte:  Animal Genetics. 2006, 37 : 335-341
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