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Provedor de dados:  Inra
País:  France
Título:  Antibody responses to keyhole limpet hemocyanin, lipopolysaccharide and Newcastle disease virus vaccine in F2 and backcrosses of White Leghorn lines selected for two different immune response traits
Autores:  Minozzi, G.
PARMENTIER, H.K.
NIEUWLAND, M.G.B.
Bed'Hom, B.
Minvielle, F.
Gourichon, D.
PINARD-VAN DER LAAN, M.H.
Data:  2007
Ano:  2007
Palavras-chave:  PRIMARY ANTIBODY RESPONSE
CHICKEN
KEYHOLE LIMPET HMOCYANIN
SALMONELLA ENTERIDITIS-DERIVED LIPOPOLYSACCHARIDE
SELECTION
Resumo:  Planned crosses were designed to producean F2 and 2 backcross populations from 2 lines of WhiteLeghorn chickens previously selected over 10 generationsfor 2 different in vivo immune responses. The selectioncriteria applied on the 2 grandparental lines were as follows:high antibody response to Newcastle disease virusvaccine 3 wk after vaccination (ND3) and high cell-mediatedimmune response [response to phytohemagglutinin].Furthermore a control line was kept by randombreeding. The objective of the study was to estimate ifthe 2 selection criteria applied on the pure lines hadchanged the level of and type of immune (humoral) responseto a new antigen, keyhole limpet hemocyanin(KLH), in the various second-generation progeny groups.In addition, correlations between parameters of acquiredand innate immunity were tested. Primary total (IgT) andisotype-specific (IgG and IgM) antibody response to KLH1 wk after immunization and levels of natural antibodies(NAB) binding to Salmonella enteriditis-derived lipopoly-saccharide (LPS) were measured. Although no differenceswere present between IgM and IgG antibodies to KLHand the phytohemagglutinin skin-swelling response, significantdifferences were present between all the progenygroups for IgT to KLH and ND3 and NAB binding toLPS. The mean values for IgT to ND3 and KLH weresignificantly different between the crosses using the selectedlines compared with the control line, indicating acontribution of the previous selection. In addition, a sexeffect was found for IgM to KLH and NAB to LPS, forwhich females had a higher response than males in bothcases. No interaction between progeny type and sex wasfound. Furthermore, significant positive correlations werefound between NAB to LPS and specific antibody titersto KLH. Finally, the results of the present study demonstratedan interaction between innate and acquired immunityunder this strategy of selection and crossbreedingand confirmed the effect of selection on general immuneresponse to a new antigen in second-generation crosses.
Tipo:  Journal Article
Idioma:  Inglês
Identificador:  http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2008781c73d2&uri=/notices/prodinra1/2008/08/

http://www.prodinra.inra.fr/prodinra/pinra/data/2008/05/PROD2008781c73d2_20080522062232269.pdf
Formato:  application/pdf
Fonte:  Poultry Science. 2007, 86 : 1316-1322
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