Sabiia Seb
        Busca avançada

Botão Atualizar

Botão Atualizar

Registro completo
Provedor de dados:  OAK
País:  Japan
Título:  Cellular localization of Babesia bovis rhoptry-associated protein 1 in the merozoite stage with immuno-electron microscopy
Autores:  Matsuo, Tomohide
Yokoyama, Naoaki
Suthisak, Boonchit
Fujisaki, Kozo
Igarashi, Ikuo
Data:  2005
Ano:  2005
Palavras-chave:  Babesia bovis RAP-1 invasion
Escape RBC
Resumo:  We examined the detailed cellular localization of the rhoptry-associated protein-1 (RAP-1) of Babesia bovis merozoites by the post-embedding method of immuno-electron microscopy (IEM) using the anti-RAP-1 monoclonal antibody (mAb) 1C1 in order to substantiate the result in our previous report by an indirect immunofluorescent antibody test and the pre-embedding method of IEM. RAP-1 slightly distributed only in cytoplasm of merozoites, especially around the nucleus, but not in the rhoptry organelle at an early stage after invasion into a red blood cell. Then, the RAP-1 was accumulated in the rhoptry organelle and was also found in the iRBC cytoplasm, which suggests that synthesis and release of RAP-1 may occur in the iRBC. Finally, the RAP-1 was found within and around merozoites after the breakdown of the iRBC. The results of the present study suggest that the RAP-1 of B. bovis merozoites functions not only in the invasion into RBC but also in the escape from iRBC.
Idioma:  Inglês
Editor:  National Research Center for Protozoan Diseases
Formato:  application/pdf

Empresa Brasileira de Pesquisa Agropecuária - Embrapa
Todos os direitos reservados, conforme Lei n° 9.610
Política de Privacidade
Área restrita

Parque Estação Biológica - PqEB s/n°
Brasília, DF - Brasil - CEP 70770-901
Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC:

Valid HTML 4.01 Transitional