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Provedor de dados:  Anais da ABC (AABC)
País:  Brazil
Título:  Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention
Autores:  MORAES,GREICE G.
REUTER,CÉZANE P.
RENNER,JANE D.P.
KLINGER,ELISA I.
FERREIRA,MICHELE B.
MELLO,ELZA D. DE
VALIM,ANDRÉIA DE M.
BURGOS,MIRIA S.
Data:  2016-12-01
Ano:  2016
Palavras-chave:  Genotype
Intervention
Obesity
Children
Physical activity
Resumo:  ABSTRACT Background: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention. Methods: The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate aminotransferase, insulin and adiponectin) and blood pressure. The 4-month intervention consisted of physical education classes, nutritional counseling, and postural and oral health counseling. Results: We observed no significant differences among the groups (AA, AT and TT) after the intervention. However, we observed improvements in three parameters (waist circumference, hip circumference and C-reactive protein) in the AT/AA genotype group and in two parameters (hip circumference and uric acid) in the TT genotype group. Conclusions: After an intervention program, carriers of at-risk genotypes for obesity (AA/AT) do not exhibit differences in biochemical parameters, blood pressure and anthropometric parameters compared with carriers of the TT genotype.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602331
Editor:  Academia Brasileira de Ciências
Relação:  10.1590/0001-3765201620160114
Formato:  text/html
Fonte:  Anais da Academia Brasileira de Ciências v.88 n.4 2016
Direitos:  info:eu-repo/semantics/openAccess
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