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Provedor de dados:  Biol. Res.
País:  Chile
Título:  Phospholipid synthesis, diacylglycerol compartmentation, and apoptosis
Data:  2002-01-01
Ano:  2002
Palavras-chave:  Apoptosis
Phorbol ester
Protein kinase C
Resumo:  Apoptosis is a means by which organisms dispose of unwanted cells without inducing an inflammatory response. Alterations in apoptosis is a common process by which cells become cancerous. Paradoxically, many cancer chemotherapeutics preferentially kill cancer cells by inducing apoptosis. Diacylglycerol is a lipid second messenger that regulates cell growth and apoptosis and is produced during signal transduction by hydrolysis of membrane phospholipids. Protein kinase Cs are a family of diacylglycerol responsive enzymes that are recruited to cellular membranes as a consequence of diacylglycerol production where they phosphorylate specific target proteins responsible for regulating cell growth. In this review, we will first summarize our current understanding of the role of specific proteins kinase C isoforms in the induction of cell growth/apoptosis. Subsequently, we will discuss how insights gained in lipid-mediated regulation of protein kinase Cs promotes our understanding of the role specific family members play in regulating cell growth. Finally, other diacylglycerol binding proteins involved in regulating apoptosis will be discussed
Tipo:  Journal article
Idioma:  Inglês
Editor:  Sociedad de Biología de Chile
Formato:  text/html
Fonte:  Biological Research v.35 n.2 2002

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