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Provedor de dados:  ArchiMer
País:  France
Título:  Quorum sensing inhibitors from Leucetta chagosensis Dendy, 1863
Autores:  Mai, T.
Tintillier, Florent
Lucasson, Aude
Moriou, C.
Bonno, E.
Petek, S.
Magre, Kevin
Al Mourabit, A.
Saulnier, Denis
Debitus, C.
Data:  2015-10
Ano:  2015
Palavras-chave:  Biofouling
Leucetta chagosensis
Quorum sensing
Quorum sensing inhibitors
Vibrio harveyi
Resumo:  Sponges are a rich source for investigation of bioactive small molecules. They have been mostly investigated for the search of new pharmacological models or therapeutic agents for the treatment of human diseases. Micro-organisms can also represent a virulent pathogen for marine invertebrates such as sponges, which need to protect themselves against these microbes. Sponges' self defence mechanisms involving dialogue molecules thus represent a pertinent research track for potent anti-infective and anti-biofilm activities such as quorum sensing inhibitors (QSIs). The investigation of the QSI crude extract of Leucetta chagosensis Dendy, 1863 led to the isolation of three new alkaloids, isonaamine D, di-isonaamidine A and leucettamine D, along with the known isonaamine A and isonaamidine A. Isonaamidine A and isonaamine D were identified as inhibitors of the three quorum sensing pathways of Vibrio harveyi (CAI-1, AI-2 and harveyi auto inducer), but isonaamidine A displayed the strongest activity on AI-2 biosensor. Both compounds are new examples of natural QSIs of V. harveyi. These results outline the importance of these secondary metabolites for their producing organisms themselves in their natural environment, as well as the potential of the marine resource for aquaculture needs.
Tipo:  Text
Idioma:  Inglês

Editor:  Wiley-blackwell
Formato:  application/pdf
Fonte:  Letters In Applied Microbiology (0266-8254) (Wiley-blackwell), 2015-10 , Vol. 61 , N. 4 , P. 311-317
Direitos:  2015 The Society for Applied Microbiology


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