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Provedor de dados:  ArchiMer
País:  France
Título:  Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters
Autores:  De Lorgeril, Julien
Lucasson, Aude
Petton, Bruno
Toulza, Eve
Montagnani, Caroline
Clerissi, Camille
Vidal-dupiol, Jeremie
Chaparro, Cristian
Galinier, Richard
Escoubas, Jean Michel
Haffner, Philippe
Degremont, Lionel
Charriere, Guillaume
Lafont, Maxime
Delort, Abigail
Vergnes, Agnes
Chiarello, Marlene
Faury, Nicole
Rubio, Tristan
Leroy, Marc
Perignon, Adeline
Regler, Denis
Morga, Benjamin
Alunno-bruscia, Marianne
Boudry, Pierre
Le Roux, Frederique
Destoumieux-garzon, Delphine
Gueguen, Yannick
Mitta, Guillaume
Data:  2018-10
Ano:  2018
Resumo:  Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly in fluenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 μVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide.
Tipo:  Text
Idioma:  Inglês

Editor:  Nature Publishing Group
Relação:  info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI
Formato:  application/pdf
Fonte:  Nature Communications (2041-1723) (Nature Publishing Group), 2018-10 , Vol. 9 , N. 4215 , P. 14p.
Direitos:  The Author(s) 2018


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