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Provedor de dados:  ArchiMer
País:  France
Título:  Sterilization of Exopolysaccharides Produced by Deep-Sea Bacteria: Impact on Their Stability and Degradation
Autores:  Rederstorff, Emilie
Fatimi, Ahmed
Sinquin, Corinne
Ratiskol, Jacqueline
Merceron, Christophe
Vinatier, Claire
Weiss, Pierre
Colliec-jouault, Sylvia
Data:  2011-02
Ano:  2011
Palavras-chave:  Marine biotechnology
Sterilization procedures
Molecular weight distribution
Resumo:  Polysaccharides are highly heat-sensitive macromolecules, so high temperature treatments are greatly destructive and cause considerable damage, such as a great decrease in both viscosity and molecular weight of the polymer. The technical feasibility of the production of exopolysaccharides by deep-sea bacteria Vibrio diabolicus and Alteromonas infernus was previously demonstrated using a bioproduct manufacturing process. The objective of this study was to determine which sterilization method, other than heat sterilization, was the most appropriate for these marine exopolysaccharides and was in accordance with bioprocess engineering requirements. Chemical sterilization using low-temperature ethylene oxide and a mixture of ionized gases (plasmas) was compared to the sterilization methods using gamma and beta radiations. The changes to both the physical and chemical properties of the sterilized exopolysaccharides were analyzed. The use of ethylene oxide can be recommended for the sterilization of polysaccharides as a weak effect on both rheological and structural properties was observed. This low-temperature gas sterilizing process is very efficient, giving a good Sterility Assurance Level (SAL), and is also well suited to large-scale compound manufacturing in the pharmaceutical industry.
Tipo:  Text
Idioma:  Inglês

Editor:  Mdpi Ag
Formato:  application/pdf
Fonte:  Marine Drugs (1660-3397) (Mdpi Ag), 2011-02 , Vol. 9 , N. 2 , P. 224-241
Direitos:  2011 MDPI Publishing

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