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Provedor de dados:  ArchiMer
País:  France
Título:  A Sustained Immune Response Supports Long-Term Antiviral Immune Priming in the Pacific Oyster, Crassostrea gigas
Autores:  Lafont, Maxime
Vergnes, Agnes
Vidal-dupiol, Jeremie
De Lorgeril, Julien
Gueguen, Yannick
Haffner, Philippe
Petton, Bruno
Chaparro, Cristian
Barrachina, Celia
Destoumieux-garzon, Delphine
Mitta, Guillaume
Gourbal, Benjamin
Montagnani, Caroline
Data:  2020-04
Ano:  2020
Palavras-chave:  Innate immunity
Antiviral response
Immune memory
Resumo:  Over the last decade, innate immune priming has been evidenced in many invertebrate phyla. If mechanistic models have been proposed, molecular studies aiming to substantiate these models have remained scarce. We reveal here the transcriptional signature associated with immune priming in the oyster Crassostrea gigas. Oysters were fully protected against Ostreid herpesvirus 1 (OsHV-1), a major oyster pathogen, after priming with poly(I·C), which mimics viral double-stranded RNA. Global analysis through RNA sequencing of oyster and viral genes after immune priming and viral infection revealed that poly(I·C) induces a strong antiviral response that impairs OsHV-1 replication. Protection is based on a sustained upregulation of immune genes, notably genes involved in the interferon pathway and apoptosis, which control subsequent viral infection. This persistent antiviral alert state remains active over 4 months and supports antiviral protection in the long term. This acquired resistance mechanism reinforces the molecular foundations of the sustained response model of immune priming. It further opens the way to applications (pseudovaccination) to cope with a recurrent disease that causes dramatic economic losses in the shellfish farming industry worldwide.
Tipo:  Text
Idioma:  Inglês

Editor:  American Society for Microbiology
Relação:  info:eu-repo/grantAgreement/EC/FP7/678589/EU//VIVALDI
Formato:  application/pdf
Fonte:  mBio (2150-7511) (American Society for Microbiology), 2020-04 , Vol. 11 , P. e02777-19 (17p.)
Direitos:  info:eu-repo/semantics/openAccess

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