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Provedor de dados:  BABT
País:  Brazil
Título:  Effect of naringerin on biochemical parameters in the streptozotocin-induced diabetic rats
Autores:  Fernandes,Ana Angélica Henrique
Novelli,Ethel Lourenzi Barbosa
Fernandes Junior,Ary
Galhardi,Cristiano Machado
Data:  2009-02-01
Ano:  2009
Palavras-chave:  Naringerin
Hypoglycaemic activity
Streptozotocin
Diabetes mellitus
Aminotransferases
Hepatic
Cardiac tissues
Resumo:  Amongst the numerous co-adjuvant therapies which could influence the incidence and progression of diabetic complications, antioxidants and flavonoids are currently being tested in clinical trials. We investigated the effect of naringerin on biochemical parameters in streptozotocin-induced (STZ - 60 mg/kg, i.p.) diabetic rats. Male rats were divided into four groups: G1: untreated controls; G2: normal rats receiving naringerin; G3: untreated diabetics; G4: diabetics rats receiving naringerin. The naringerin (50mg/kg, i.p,) decreased the hyperglycaemia and hyperlipidaemia associated with STZ-diabetes. The concentrations of serum insulin in treated diabetic rats tended to be increased. Naringerin treatment prevents STZ-induced changes in the activities of ALT, AST and LDH in the liver and heart, indicating the protective effect of naringerin against the hepatic and cardiac toxicity caused by STZ. The glycogen level in cardiac and hepatic tissues elevated with naringerin in diabetic rats. The naringerin can improve the glucose and lipid metabolism and is beneficial in preventing diabetic complications.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000100007
Editor:  Instituto de Tecnologia do Paraná - Tecpar
Relação:  10.1590/S1516-89132009000100007
Formato:  text/html
Fonte:  Brazilian Archives of Biology and Technology v.52 n.1 2009
Direitos:  info:eu-repo/semantics/openAccess
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