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Provedor de dados:  BJMBR
País:  Brazil
Título:  DNA encoding individual mycobacterial antigens protects mice against tuberculosis
Autores:  Silva,C.L.
Data:  1999-02-01
Ano:  1999
Palavras-chave:  Tuberculosis
DNA vaccination
Resumo:  Over the last few years, some of our experiments in which mycobacterial antigens were presented to the immune system as if they were viral antigens have had a significant impact on our understanding of protective immunity against tuberculosis. They have also markedly enhanced the prospects for new vaccines. We now know that individual mycobacterial protein antigens can confer protection equal to that from live BCG vaccine in mice. A critical determinant of the outcome of immunization appears to be the degree to which antigen-specific cytotoxic T cells are generated by the immune response. Our most recent studies indicate that DNA vaccination is an effective way to establish long-lasting cytotoxic T cell memory and protection against tuberculosis.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X1999000200012
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.32 n.2 1999
Direitos:  info:eu-repo/semantics/openAccess

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