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Provedor de dados:  BJMBR
País:  Brazil
Título:  Expression of BAFF and BR3 in patients with systemic lupus erythematosus
Autores:  Duan,J.H.
Jiang,Y.
Mu,H.
Tang,Z.Q.
Data:  2016-03-01
Ano:  2016
Palavras-chave:  Systemic lupus erythematosus
Peripheral blood mononuclear cells
B cell-activating factor
BAFF receptor
Resumo:  The objective of this study was to examine the relationship between the expression of B cell activating factor (BAFF) and BAFF receptor in patients with disease activity of systemic lupus erythematosus (SLE). Real-time RT-PCR was used to examine BAFF mRNA expression in peripheral blood monocytes of active and stable SLE patients and healthy controls. The percentage of BAFF receptor 3 (BR3) on B lymphocytes was measured by flow cytometry. Soluble BAFF levels in serum were assayed by ELISA. Microalbumin levels were assayed by an automatic immune analysis machine. BAFF mRNA and soluble BAFF levels were highest in the active SLE group, followed by the stable SLE group, and controls (P<0.01). The percentage of BR3 on B lymphocytes was downregulated in the active SLE group compared with the stable SLE group and controls (P<0.01). BAFF mRNA levels and soluble BAFF levels were higher in patients who were positive for proteinuria than in those who were negative (P<0.01). The percentage of BR3 on B lymphocytes was lower in patients who were positive for proteinuria than in those who were negative (P<0.01). The BAFF/BR3 axis may be over-activated in SLE patients. BAFF and BR3 levels may be useful parameters for evaluating treatment.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000300706
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/1414-431X20154853
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.49 n.3 2016
Direitos:  info:eu-repo/semantics/openAccess
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