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Provedor de dados:  BJMBR
País:  Brazil
Título:  Galectin-1, an alternative signal for T cell death, is increased in activated macrophages
Autores:  Rabinovich,G.A.
Riera,C.M.
Sotomayor,C.E.
Data:  1999-05-01
Ano:  1999
Palavras-chave:  Galectin-1
Apoptosis
Immunomodulation
Macrophage
Resumo:  Galectin-1 belongs to an evolutionarily conserved family of animal ß-galactoside-binding proteins, which exert their functions by crosslinking the oligosaccharides of specific glycoconjugate ligands. During the past decade, attempts to identify the functional role of galectin-1 suggested participation in the regulation of the immune response. Only in the last few years has the molecular mechanism involved in these properties been clearly elucidated, revealing a critical role for galectin-1 as an alternative signal in the generation of T cell death. In the present study we will discuss the latest advances in galectin research in the context of the regulation of the immune response, not only at the central level but also at the periphery. Moreover, we will review the purification, biochemical properties and functional significance of a novel galectin-1-like protein from activated rat macrophages, whose expression is differentially regulated according to the activation state of the cells. The novel role of a carbohydrate-binding protein in the regulation of apoptosis is providing a breakthrough in galectin research and extending the interface between immunology, glycobiology and clinical medicine.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500009
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/S0100-879X1999000500009
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.32 n.5 1999
Direitos:  info:eu-repo/semantics/openAccess
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