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Provedor de dados:  International Journal of Morphology
País:  Chile
Título:  Quantitative Analysis of Collagen Fibrillar Structure in Canine Uterus Exposed to Acetate of Medroxyprogesterone Using Second Harmonic Generation Microscopy
Autores:  Salinas,Paulo
Miglino,Maria Angélica
del Sol,Mariano
Data:  2017-03-01
Ano:  2017
Palavras-chave:  Canine
Medroxyprogesterone acetate
Second harmonic generation
Resumo:  Collagen is the most abundant structural protein found in organs and is responsible for providing tissues with structure and function. In order to investigate in canine uteri the potential effect of medroxyprogesterone acetate (MPA) on the changes in collagen deposition were grouped as nulliparous (n=11), multiparous (n=11) and treated with MPA (n=11; nulliparous with two treatments; 5 mg/kg; i.m.). The amount of collagen was studied in the fold and basal regions of the endometrium and myometrium using second harmonic generation with a two-photon spectral confocal microscope, quantified using ImageJ software with a color segmentation plugin, was expressed as fraction area (%) and analyzed by ANOVA (p<0,05). No differences were observed between groups in the fold (p=0,3995) or base (p=0,7392) of the endometrium and myometrium (p=0,1781). In conclusion, our data demonstrate that two doses of MPA (5 mg/kg; i.m.) do not affect the total collagen deposition in canine uteri undergoing contraceptive treatment.
Tipo:  Journal article
Idioma:  Inglês
Editor:  Sociedad Chilena de Anatomía
Formato:  text/html
Fonte:  International Journal of Morphology v.35 n.1 2017

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