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Provedor de dados:  International Journal of Morphology
País:  Chile
Título:  Immunohistochemical Analysis of Human Homologue of Drosophila Patched (PTCH) in Dental Follicles of Impacted Third Molars
Autores:  Oliveira,David Moraes de
Silveira,Márcia Maria Ferreira da
Andrade,Emanuel Sávio de Souza
Sobral,Ana Paula Veras
Martins-Filho,Paulo Ricardo Saquete
Santos,Thiago de Santana
Oliveira,Patrícia Leimig Amorim de
Peixoto,Aline Carvalho
Santos,Jadson Alípio Santana de Souza
Piva,Marta Rabello
Data:  2012-03-01
Ano:  2012
Palavras-chave:  Immunohistochemistry
Dental follicle
Odontogenic epithelial
PTCH
Resumo:  This study investigated the immunodetection of PTCH in epithelial components of dental follicles associated with impacted third molars without radiographic signs of pathosis. One hundred and five specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla's stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferation was determined by using immunohistochemical labeling. Statistical analysis was performed using Fisher exact test and a level of significance of 5%. Of the 105 dental follicles collected, 3 were PTCH-positive. The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PTCH, as well as those with active remnants of odontogenic epithelium. This study suggests that the odontogenic cells of the dental follicle might be proliferating during the rhizogenesis, while the squamous metaplasia and hyperplasia of the epithelial lining and proliferative odontogenic epithelial rests show the differentiation potential of dental follicles.
Tipo:  Journal article
Idioma:  Inglês
Identificador:  http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100018
Editor:  Sociedad Chilena de Anatomía
Formato:  text/html
Fonte:  International Journal of Morphology v.30 n.1 2012
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