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Provedor de dados:  International Journal of Morphology
País:  Chile
Título:  Histopathology of Organs from Neonate Offspring Born to Female Rats Exposed to Sublethal Doses of Biological and Synthetic Insecticides
Autores:  dos Santos,Hilda Michelly Paiva
Teixeira,Valéria Wanderley
Teixeira,Álvaro Aguiar Coelho
da Silva,Rosimere
Lemos,Ana Janaina Jeanine Martins
Neto,Clovis José Cavalcanti Lapa
Ferreira,Cintia Giselle Martins
Data:  2013-03-01
Ano:  2013
Palavras-chave:  Bacillus thuringiensis
Synthetic insecticide
Resumo:  The current annual consumption of insecticides in agriculture in Brazil is over three million tons. The exposure happens through food that is contaminated with toxic waste and respiratory and dermal absorption. Biological control with Bacillus thuringiensis Berliner (Bt) has assumed increasing importance replacing the use of conventional insecticides. However, the tests used to justify approval for use and market release of Bt products, and the protocols used to assess the development of toxicity, are extremely superficial. In addition, more studies comparing effects between males and females and during pregnancy and lactation have not been conducted. Thus, the hypothesis tested in this study was if the administration of the XenTari® WG (Bacillus thuringiensis subsp. Aizawai) biological insecticide and Decis® 25CE (Deltamethrin) synthetic insecticide, at concentrations that do not cause clinical signs of maternal toxicity, could interfere in the histophysiology of the organs of neonate rats. Thirty-five pregnant albino rats, Rattus norvegicus albinus, were randomly distributed in seven groups: Group I received placebo (water); Groups II, III, and IV received 1.0, 10.0, and 20.0 mg of XenTari®/kg respectively; and Groups V, VI, and VII received 1.0, 2.0, and 4.0 mg of Deltamethrin/kg, respectively. The results showed that the highest doses of insecticides reduced the number of neonates. No histopathological alterations were observed in the kidneys, however, lipidosis, diffuse mononuclear inflammatory cells, and sinusoids congestion were observed in the liver. Rats from groups IV and VII presented atresia in the ovaries. Neonates from Group IV showed congestion and hemosiderin deposition in the testicle's blood vessels, which is characteristic of a process of hemolysis. In conclusion, both insecticides presented similar effects on organs and number of neonates born to rats exposed to sub-lethal doses that did not cause clinical symptoms of maternal intoxication.
Tipo:  Journal article
Idioma:  Inglês
Editor:  Sociedad Chilena de Anatomía
Formato:  text/html
Fonte:  International Journal of Morphology v.31 n.1 2013

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