Consulta: creatorFacets:"Abrahamsohn,I.A."
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Data/hora: 01/06/2024 08:32:58

Cytokines in innate and acquired immunity to Trypanosoma cruzi infection
Provedor de dados: 56
Autores: Abrahamsohn,I.A.
Resistance to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of the vertebrate host. A study performed on mice with disrupted recombinase-activating genes (RAG/KO), which lack T and B lymphocytes, revealed the importance of IL-12, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; and TNF-&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt; in the resistance against T. cruzi mediated by the innate immune system. In addition, data from experiments using IL-10 KO, RAG/KO and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Interferon-gamma; Interleukin-12; TNF-alpha; Interleukin-10; Innate immunity; Knock-out mice.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100015