Consulta: creatorFacets:"Adams,Andréa Inês Horn"
Registros recuperados: 2
Data/hora: 06/06/2024 04:34:08

A fully validated microbiological assay for daptomycin injection and comparison to HPLC method
Provedor de dados: 60
Autores: Christ,Ana Paula; Machado,Mariana Souto; Ribas,Karla Giacomelli; Schwarzbold,Alexandre Vargas; Silva,Cristiane de Bona da; Adams,Andréa Inês Horn.
abstract Daptomycin (DPT) was the first lipopeptide antibiotic available for commercialization. It is active against gram-positive bacteria, including resistant strains. This work aimed to develop and validate a turbidimetric microbiologic assay to determine daptomycin in an injectable form. A 3x3 design was employed, at concentrations of 1, 2 and 4.0 µg/mL. The microorganism test used was Staphylococcus aureus ATCC 6538p, and Antibiotic Medium 3 was used as the culture medium. Method validation demonstrated that the bioassay was linear (r=0.9995), precise (RSD=2.58%), accurate (recovery 100.48± 2.11%), and robust. Degradation kinetics was also performed in an alkaline medium, indicating that daptomycin degradation follows first order kinetics under these...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Daptomycin/determination; Daptomycin injection/quality control; Turbidimetric microbiological assay/quantitative analysis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400775

Stability indicating RP-LC-PDA method for the quantitative analysis of saxagliptin in pharmaceutical dosage form
Provedor de dados: 60
Autores: Scheeren,Laís Engroff; Marcolino,Ana Isa Pedroso; Adams,Andréa Inês Horn; Rolim,Clarice Madalena Bueno.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Saxagliptin/tablets/quality control; High Performance Liquid Chromatography/quantitative analysis.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000200461