Consulta: creatorFacets:"Albuquerque Júnior,Ricardo Luiz Cavalcanti de"
Registros recuperados: 2
Data/hora: 01/06/2024 06:01:01

Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model
Provedor de dados: 77
Autores: Pereira-Filho,Rose Nely; Batista,Fellipe Santos; Ribeiro,Danielle Rodrigues; Melo,Genecy Calado de; Reis,Francisco Prado; Melo,Allan Ulisses Carvalho de; Gomes,Margarete Zanardo; Cardoso,Juliana Cordeiro; Albuquerque Júnior,Ricardo Luiz Cavalcanti de.
The aim of this study was to assess the effect of oral administration of Hydroalcoholic Extract of Green Propolis (HEGP) on dermal carcinogenesis in rodent model. For the biological assay, we used 36 mice, assigned into 6 groups (n=6): CTR (treated with 100 mg/kg HEGP and no tumor induction), TUM (treated with water and tumor induction), GP10 (treated with 10 mg/kg HEGP and tumor induction), GP50 (treated with 50 mg/kg HEGP and tumor induction) and GP100 (treated with 100 mg/kg HEGP and tumor induction). Cancer induction was performed in the back of the mice by topical application of DMBA. After 16 weeks, mice were euthanized and their backs were submitted to post-mortem histological analysis. The mean number of lesions developed in TUM (4.14±0.89) was...
Tipo: Journal article
Palavras-chave: Propolis; Skin cancer.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200024

Death-Associated Protein Kinase is Underexpressed in High-Grade Oral Squamous Cell Carcinoma
Provedor de dados: 77
Autores: Meneses,Ismário Silva de; Souza,Rafael Reis de; Jeraldo,Verónica de Lourdes Sierpe; Cavalcante,Danielle Rodrigues Ribeiro; Reis,Francisco Prado; Albuquerque Júnior,Ricardo Luiz Cavalcanti de.
An immunohistochemical analysis of 40 cases of oral squamous cell carcinoma was performed to evaluate the relationship between the expression pattern of death-associated protein kinase (DAPk) positive cells with the histological malignancy grading of these lesions. According to our results, eleven cases (27.5%) were high-grade malignancy tumours and 29 (72.5%) were low-grade ones. We found that 92.86% of the low-grade tumours were positive to anti-DAP kinase antibody whereas only 7.14% of the high-grade tumours presented positivity, and this difference was statistically significant (p&lt;0.01). Sixteen (55.2%) of the low-grade carcinomas exhibited moderate immunoreactivity whereas ten cases (34.5%) showed weak staining and three cases (10.3%) were negative...
Tipo: Journal article
Palavras-chave: Immunohistochemistry; DAP kinase; Apoptosis; Squamous cell carcinoma.
Ano: 2010
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200044