Consulta: creatorFacets:"BUTLER,T. L."
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Data/hora: 01/06/2024 01:34:04

AN IN VITRO STUDY OF THE EFFECTS OF VENOM OF AUSTRALIAN ELAPIDS ON MURINE SKELETAL MUSCLE AND THE PROTECTIVE EFFECT OF HOMOLOGOUS PLASMA
Provedor de dados: 79
Autores: BUTLER,T. L.; JACOBSEN,P. F.; MIRTSCHIN,P. J.; KAKULAS,B. A.
The venom of many dangerous Australian snakes has a myotoxic component and some are strongly myolytic. The myotoxicity of venom of seven Australian elapid snakes was studied to determine their relative in vitro potency in causing cell death of C2C12 cells, a myoblast cell line, and murine myotubes in mixed cell culture. The venom of Pseudechis australis proved to be the most myotoxic, Austrelaps superbus and Pseudechis porphyriacus venoms also exhibited high myotoxicity relative to the other venoms tested. The specificity of Pseudechis porphyriacus venom was tested using the human glioma cell line TC3 and was shown to exhibit a general cytotoxicity. Myotoxicity, however, was the predominant action of the venom. It has long been known that certain animals...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Snake venom antidote; Plasma; Myotoxicity; Murine skeletal muscle; Australian elapids.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301998000100004