Consulta: creatorFacets:"Barral,Aldina"
Registros recuperados: 2
Data/hora: 01/06/2024 01:12:22

Haematophagous arthropod saliva and host defense system: a tale of tear and blood
Provedor de dados: 42
Autores: Andrade,Bruno B.; Teixeira,Clarissa R.; Barral,Aldina; Barral-Netto,Manoel.
The saliva from blood-feeding arthropod vectors is enriched with molecules that display diverse functions that mediate a successful blood meal. They function not only as weapons against host's haemostatic, inflammatory and immune responses but also as important tools to pathogen establishment. Parasites, virus and bacteria taking advantage of vectors' armament have adapted to facilitate their entry in the host. Today, many salivary molecules have been identified and characterized as new targets to the development of future vaccines. Here we focus on current information on vector's saliva and the molecules responsible to modify host's hemostasis and immune response, also regarding their role in disease transmission.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Saliva; Bites; Hemostasis; Host; Vector; Infection.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000400008

In vitro initial immune response against Leishmania amazonensis infection is characterized by an increased production of IL-10 and IL-13
Provedor de dados: 55
Autores: Coêlho,Zirlane Castelo B; Teixeira,Maria Jania; Mota,Erika Freitas; Frutuoso,Mércia Sindeaux; Silva,João Santana da; Barral,Aldina; Barral-Netto,Manoel; Pompeu,Margarida Maria L.
The initial encounter of Leishmania with its host's immune system is important in the outcome of infection. Previous studies have shown that PBMCs from healthy volunteers (HV) exposed to Leishmania differ in IFN-γ production. We have expanded such observations evaluating the profile and kinetics of cytokines (IFN-γ, IL-12p70, IL-10, IL-13), chemokines (CCL5, CCL3, CCL4, CXCL10), and chemokine receptors (CCR1,CCR5, CXCR3, CCR4) in vitro L. amazonensis-stimulated of HV's PBMCs. HVs were divided in groups of high (HR) or low (LR) IFN-γ responders. In both groups, HR and LR, after L. amazonensis infection there was a predominance of IL-10 and IL-13 over IFN-γ production, while IL-12 was produced in similar amount. Regarding chemokines, a more striking...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmania amazonensis; Interleukin-10; Interleukin-13.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500009