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Genetic polymorphisms and asthma: findings from a case - control study in the Madeira island population
Provedor de dados: 48
Autores: Berenguer,Anabela Gonçalves; Fernandes,Ana Teresa; Oliveira,Susana; Rodrigues,Mariana; Ornelas,Pedro; Romeira,Diogo; Serrão,Tânia; Rosa,Alexandra; Câmara,Rita.
BACKGROUND: Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Global Initiative for Asthma (GINA) guidelines, established their sensitization profile, and measured their forced expiratory volume in 1second (FEV1) and forced vital capacity (FVC) indexes. Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33),...
Tipo: Journal article
Palavras-chave: Asthma; Madeira; SNPs; Susceptibility; Severity.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100040