Consulta: creatorFacets:"CASTRO,ADALBERTO A. DE"
Registros recuperados: 2
Data/hora: 11/06/2024 18:08:21

Olfactory deficit as a result of clozapine withdrawal syndrome in an animal model of schizophrenia: preliminary results
Provedor de dados: 42
Autores: PACHECO,FELIPE D.; SILVA,MAURICIO L. DA; BATISTA,GRAZIELA; SANTOS,WITÓRIA; CASTRO,ADALBERTO A. DE; CANEVER,LARA; ZUGNO,ALEXANDRA I.
ABSTRACT Clozapine is an antipsychotic that produces serious withdrawal effects in schizophrenic patients. Olfactory deficits are well known as part of negative symptoms, but it is not known whether antipsychotic use and/or withdrawal are implicated. Then, we tested clozapine withdrawal in association with two widely used schizophrenia models: Neonatal immune challenge by Polycitidilic-polyinosinic acid (polyI:C) and ketamine. PolyI:C (or saline) was injected subcutaneously in neonatal period, dose of 5 mg/kg from 2 to 6 Post Natal Days, and ketamine or saline at the dose 25mg/kg intraperitoneally (i.p.), daily for 7 days from 53 to 60 post natal day. Clozapine 10mg/kg (or saline) was administered i.p. from 46 to 60 post natal day. Olfactory discrimination...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Olfactory deficit; Clozapine; Schizophrenia; Animal model.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000401659

The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine
Provedor de dados: 42
Autores: DAMAZIO,LOUYSE S.; SILVEIRA,FLÁVIA R.; CANEVER,LARA; CASTRO,ADALBERTO A. DE; ESTRELA,JADNE M.; BUDNI,JOSIANE; ZUGNO,ALEXANDRA I.
ABSTRACT Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) in an animal model of schizophrenia (SZ). Rats were supplemented with AA (0.1, 1, or 10 mg/kg), or water for 14 days (gavage). Between the 9th and 15th days, the animals received Ketamine (Ket) (25 mg/kg) or saline (i.p). After the last administration (30 min) rats were subjected to the behavioral test. Brain structures were dissected for biochemical analysis. There was a significant increase in the locomotor activity in Ket treated. AA prevented the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Schizophrenia; Ascorbic acid; Ketamine; Hyperlocomotion; Acetylcholinesterase.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301133