Consulta: creatorFacets:"Calvo,Juan Carlos"
Registros recuperados: 1
Data/hora: 01/06/2024 09:48:12

Interleukin-1&amp;#946; regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model
Provedor de dados: 47
Autores: Fontana,Vanina Andrea; Sanchez,Melisa; Cebral,Elisa; Calvo,Juan Carlos.
Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-&amp;#946; on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1&amp;#946; activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytokines; Embryo implantation; Placenta; Extracellular matrix.
Ano: 2010
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000100005