Consulta: creatorFacets:"Cardoso-Lopes,Elaine Monteiro"
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Data/hora: 05/06/2024 09:06:37

Chemical composition, acetylcholinesterase inhibitory and antifungal activities of Pera glabrata (Schott) Baill. (Euphorbiaceae)
Provedor de dados: 88
Autores: Cardoso-Lopes,Elaine Monteiro; Paula,Daisy Maria Bentes de; Barbo,Fausto Erritto; Souza,Amanda de; Blatt,Cecília Terumi Teradaira; Torres,Luce Maria Brandão; Young,Maria Cláudia Marx.
Pera glabrata (Schott) Baill. was selected for this study after showing a preliminary positive result in a screening of Atlantic Forest plant species in the search for acetylcholinesterase inhibitors and antifungal compounds. The bioassays were conducted with crude ethanol extract of the leaves using direct bioautography method for acetylcholinesterase and antifungal activities. This extract was partitioned with hexane, chloroform and ethyl acetate solvents. The active chloroform fraction was submitted to silica gel chromatography column affording 12 groups. Caffeine, an alkaloid, which showed detection limits of 0.1 and 1.0 µg for anticholinesterasic and antifungal activities, respectively, was isolated from group nine. After microplate analyses, only...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: 9-hydroxy-4-megastigmen-3-one; Biological activities; Caffeine; Euphorbiaceae.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84042009000400019