Consulta: creatorFacets:"Flamm,Robert K."
Registros recuperados: 3
Data/hora: 10/06/2024 16:34:36

Ceftolozane-tazobactam activity against drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa causing healthcare-associated infections in Latin America: report from an antimicrobial surveillance program (2013-2015)
Provedor de dados: 55
Autores: Pfaller,Michael A.; Shortridge,Dee; Sader,Helio S.; Gales,Ana; Castanheira,Mariana; Flamm,Robert K.
ABSTRACT This study evaluated the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Latin American isolates of Enterobacteriaceae and Pseudomonas aeruginosa from patients with health care-associated infections. Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor.A total of 2415 Gram-negative organisms (537 P. aeruginosa and 1878 Enterobacteriaceae) were consecutively collected in 12 medical centers located in four Latin American countries. The organisms were tested for susceptibility by broth microdilution methods as described by the CLSI M07-A10 document and the results interpreted according to EUCAST and CLSI breakpoint criteria.  Results: Ceftolozane-tazobactam...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ceftolozane-tazobactam; Drug resistance; Enterobacteriaceae; P. aeruginosa; Latin America; Surveillance.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600627

Ceftaroline activity tested against contemporary Latin American bacterial pathogens (2011)
Provedor de dados: 55
Autores: Flamm,Robert K.; Sader,Helio S.; Jones,Ronald N.
A total of 2484 target bacterial pathogens were collected (one per patient episode) from patients in 16 Latin American medical centers located in seven nations during 2011. Isolate identity was confirmed at a coordinating laboratory and susceptibility testing was performed for ceftaroline and comparator agents according to reference broth microdilution methods. A total of 30.0% of isolates were from respiratory tract, 29.4% from skin and skin structure, 21.4% from blood stream, 7.9% from urinary tract and 11.3% from other sites. Ceftaroline was active againstStaphylococcus aureus (42.8% MRSA) with 83.6% of the isolates at &lt;1mg/L and all isolates at &lt;2mg/L (MIC5090, 0.25/2mg/L). National MRSA rates ranged from a low of 28.8% in Colombia to a high of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ceftaroline; Latin America; AWARE.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200187

Spectrum and potency of ceftaroline against leading pathogens causing community-acquired respiratory tract and skin and soft tissue infections in Latin America, 2010
Provedor de dados: 55
Autores: Flamm,Robert K.; Sader,Helio S.; Jones,Ronald N.
Ceftaroline, the active metabolite of the prodrug ceftaroline fosamil, is a cephalosporin with in vitro bactericidal activity against Gram-positive organisms, including methicillinsusceptible and -resistant Staphylococcus aureus, β-haemolytic and viridans group streptococci, and Streptococcus pneumoniae, as well as common Gram-negative organisms. In this study a total of 986 isolates collected in 2010 from patients in 15 medical centers in five Latin American countries from the Assessing Worldwide Antimicrobial Resistance Evaluation Program were identified as community-acquired respiratory tract or skin and soft tissue infection pathogens. Ceftaroline was the most potent agent tested against S. pneumoniae with a MIC90 value (0.12 µg/mL) that was eight-fold...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ceftaroline; AWARE; S. aureus; S. pneumoniae.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500009