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Hippocampal Neuronal Apoptosis in Rat Offspring Due to Gestational Diabetes
Provedor de dados: 77
Autores: Ghafari,Soraya; Asadi,Ebrahim; Shabani,Ronak; Golalipour,Mohammad Jafar.
Gestational diabetes mellitus (GDM) defined as impaired glucose tolerance affects approximately 6 % of all pregnant women who have never before had diabetes, but who do have high blood glucose levels during pregnancy. This study was done to evaluate the apoptosis in the neuronal cells in the CA1, CA2 and CA3 subfields of hippocampus and dentate gyrus in offspring of gestational diabetes at the 7, 21 and 28 d in postnatal rats. Thirty Wistar rat dams were randomly allocated in control and diabetic group. Dams in diabetic group were received 40 mg/kg/BW of streptozotocin at the first day of gestation and control groups received an equivalent volume normal saline injection intraperitoneally (IP). Six offspring of GDM and control dams, at the 7, 21, 28...
Tipo: Journal article
Palavras-chave: Gestational diabetes; Hippocampus; Neuron; Apoptosis; TUNEL Assay; Dentate gyrus; Rat.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100029

Alterations of the Giant Pyramidal Neurons (Betz Cells) in Brain Cortex of Rat Offspring Born from Gestational Diabetic Dams: A Morphometric Study
Provedor de dados: 77
Autores: Ghafari,Soraya; Golalipour,Elnaz; Golalipour,Mohammad Jafar.
A few studies reported the adverse effects of gestational diabetes on hippocampus and spinal cord of rat offspring. Giant pyramidal neurons are giant pyramidal neurons located in fifth layers of the gray matter in the primary motor cortex. Therefore, this study was conducted to determine the effect of gestational diabetes on the giant pyramidal neurons and the thickness of internal pyramidal layer in the brain cortex of rat offspring. On day 1 of gestation, 10 Wistar rat dams were randomly allocated into two control and diabetic groups. Five animals in diabetic group received 40 mg/kg/BW of Streptozotocin (intraperitoneally) and control animals received normal saline. We randomly selected six offspring of every subject in both groups at day 28, 56 and 84....
Tipo: Journal article
Palavras-chave: Gestational diabetes; Neuron; Giant pyramidal neurons; Cerebral cortex; Rat offspring.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300049

Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats
Provedor de dados: 77
Autores: Golalipour,Mohammad Jafar; Roshandel,Danial; Roshandel,Gholamreza; Ghafari,Soraya; Kalavi,Mergen; Kalavi,Khodaberdi.
Lead is one of the most important environmental pollution which is toxic to many organ systems. D-penicillamine (D-P) is a chelator drug which is used for treatment of lead toxicity for several years. This study was conducted in order to evaluate the efficacy of D-P in reducing the effects of lead on hematological indices. This study was done on 36 male adult, 6-8 weeks albino Wistar rats in Gorgan University of Medical Sciences. At first male adult rats were exposed to lead acetate in their drinking water. After 8 weeks, 6 rats were selected and blood samples were prepared to assess the effects of lead toxicity. The remained lead exposed rats were divided into recovery and treatment groups where distilled water and D-P was administered for them,...
Tipo: Journal article
Palavras-chave: Lead toxicity; D-Penicillamine; Recovery; Blood indices; Rat.
Ano: 2007
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400008

Gestational Diabetes Reduces Pancreatic Beta Cells in Rat Offspring
Provedor de dados: 77
Autores: Moharerri,Alireza; Ghafari,Soraya; Golalipour,Mohammad Jafar.
Previous study has shown the adverse effects of gestational diabetes on hippocampal and spinal cord neuronal density in animal model. This study was conducted to determine the effect of gestational diabetes on beta cells in rat pancreas in early postnatal life. In this experimental study, 10 dams randomly allocated into control and diabetic groups on day 1 of gestation. Five dams in diabetic group received 40 mg/kg/BW of streptozotocin (intraperitoneally) and control animals received normal saline. Six of 28 and 56-day-old offspring of each gestational diabetes mellitus and controls were randomly scarified and sections were taken from the pancreas and stained using Gomorra's method. The density of beta cells and number and area of pancreatic islets were...
Tipo: Journal article
Palavras-chave: Gestational diabetes; Beta cell; Pancreas; Offspring; Rat.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400034

The Preventive and Treatment Effect of Urtica dioica on Astrocyte Density in the CA1 and CA3 Subfields of Hippocampus in STZ Induced Diabetic Rats
Provedor de dados: 77
Autores: Golalipour,Mohammad Jafar; Jahanshahi,Mehrdad; Ghafari,Soraya; Afshar,Mohammad.
Several animal model studies have shown that Diabetes mellitus can affect on the activity of hippocampus astrocytes, but these studies reported controversial findings. This study was done to evaluate the preventive and treatment effect of Urtica dioica (U. dioica) on astrocytes density in the CA1 and CA3 subfields of hippocampus of streptozotocin (STZ) induced diabetic rats. Twenty-eight male albino Wistar rats were randomly allocated equally into control, diabetic, U. dioica treatment and U. dioica preventive groups. Hyperglycemia was induced by STZ (80 mg/kg/BW). One week after injection of the streptozotocin, animals in treatment group were received hydroalcoholic extract of U. dioica (100 mg/kg/BW /day) for 4 weeks by intraperitoneally. In preventive...
Tipo: Journal article
Palavras-chave: Diabetes; Astrocyte; Urtica dioica; Hippocampus; CA1; CA3; Rat.
Ano: 2013
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200057

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica
Provedor de dados: 77
Autores: Golalipour,Mohammad Jafar; Ghafari,Soraya; Latifimoghadam,Mohammad Hossein; Kaboli,Sakineh.
Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. Therefore, this study was done to evaluate the protective effect of Urtica dioica on astrocytes density of the dentate gyrus in STZ induced diabetic rats. In this experimental study, 21 male albino Wistar rats were randomly allocated equally into normal, diabetic and protective (nettle treated diabetic) groups. Hyperglycemia was induced by streptozotocin (80 mg/kg) in the animals of diabetic and treatment groups. Before induction of diabetes in animals, animals in protective group received hydroalcoholic extract of Urtica dioica (100 mg/kg/BW /day) for five days...
Tipo: Journal article
Palavras-chave: Diabetes; Astrocyte; Urtica dioica; Dentate gyrus.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400039

The Effect of Gestational Diabetes Mellitus on Sciatic Nerve in Adult Offspring Rats
Provedor de dados: 77
Autores: Ameri,Mehdi; Ghafari,Soraya; Nazari,Zahra; Mehdizadeh,Mehdi; Shekari,Majid Asadi; Golalipour,Mohammadjafar.
Gestational diabetes mellitus (GDM) is one form of diabetes affect approximately 7 % of pregnancies. Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that is associated with loss of nerve fibers, myelin abnormalities and significant decrease in the expression of myelin basic protein (MBP) in peripheral nerves. This study was done to determine the effect of induced diabetes during pregnancy on sciatic nerve in adult rat offspring. In this study, wistar rats' dams were allocated to control and diabetic groups. Diabetic rats were received 40 mg/kg/body weight of streptozotocin (STZ) on the first day of gestation. Six offspring of each group were randomly selected on 12 weeks postnatal and histopathological changes in their nerve...
Tipo: Journal article
Palavras-chave: Gestational diabetes mellitus; Sciatic nerve; Myelin basic protein; Schwannocytus (Schwann cell).
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100026

Effect of Gestational Diabetes on Neuronal Cells in Rat Cerebellum in Early Postnatal Life
Provedor de dados: 77
Autores: Razi,Elahe Mirarab; Ghafari,Soraya; Hojati,Vida; Golalipour,Mohammad Jafar.
Previous study has shown the adverse effects of gestational diabetes on hippocampal neuronal density in animal model. This study was conducted to determine the effect of gestational diabetes on rat cerebellum in early postnatal life. In this experimental study, 10 dams randomly allocated into control and diabetic groups on day 1 of gestation. Five dams in diabetic group were administered 40 mg/kg/BW (intraperitoneally) of streptozotocin and control animals received normal saline. Six offspring of each gestational diabetes mellitus and controls were randomly selected at day 7 of postnatal life. Offspring were sacrificed and coronal sections were taken from the cerebellum and stained with cresyl violet. The number of Purkinje and granular cells and thickness...
Tipo: Journal article
Palavras-chave: Gestational diabetes; Cerebellum; Purkinje cell; Granular cell; Rat.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200006

Resistance of CA1 Pyramidal Cells to STZ-Induced Diabetes in Young Rats
Provedor de dados: 77
Autores: Fazeli,Seyyed Amirhossein; Gharravi,Anneh Mohammad; Jahanshahi,Mehrdad; Ghafari,Soraya; Behnampour,Naser; Golalipour,Mohammad Jafar.
The pyramidal cell density of CA1 hippocampal subfield following STZ-induced diabetes in young rats were studied. 12 male albino 6-week Wistar rats were allocated equally in groups of normal and diabetic. Hyperglycemia induced by Streptozotocin (80 mg/kg) in animals of diabetic group. After 5 weeks of study, all the rats were sacrificed and coronal sections were taken from dorsal hippocampal formation of the right cerebral hemispheres and stained with crysel violet. The area densities of the CA1 pyramidal cells were measured and compared among two groups. No significant difference between the densities of two experimental groups was found. The results can arise from the short period of diabetes and also the possible regenerative processes in developing...
Tipo: Journal article
Palavras-chave: Pyramidal cell density; CA1; Hippocampus; Diabetes; Rat.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400006

Proliferation of the b -Cells of Pancreas in Diabetic Rats Treated with Urtica Dioica
Provedor de dados: 77
Autores: Golalipour,Mohammad Jafar; Ghafari,Soraya; Kouri,Vahid; Kestkar,Abbas Ali.
This investigation was carried out to evaluate the effect of the extract of Urtica dioica leaves on hyperglycemia and quantitative changes of b-cells in streptozotocin-diabetic rats. Forty male Wistar rats were allocated in groups of normal, diabetic, treatment and protective. Hyperglycemia induced by administrating one dose of 80 mg/kg streptozotocin (STZ) intraperitoneally. Animals in treatment group received Urtica dioica (100 mg/kg/day) for 4 weeks intraperitoneally, one week after injection of STZ. In protective group animals received U. dioica (100 mg/kg/day) for 5 days before inducing diabetes. After five weeks the animals were sacrificed and whole pancreas removed. Pancreas specimens were used for quantitative morphometric analysis after Chromealum...
Tipo: Journal article
Palavras-chave: Streptozotocin; Diabetes; Urtica dioica; Rat; Pancreas; B-cells; Blood glucose.
Ano: 2010
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200011

Can Formaldehyde Exposure Induce Histopathologic and Morphometric Changes on Rat Kidney?
Provedor de dados: 77
Autores: Golalipour,Mohammad Jafar; Azarhoush,Ramin; Ghafari,Soraya; Davarian,Ali; Fazeli,Seyyed Amirhossein.
Formaldehyde is used traditionally for fixing the cadaver, and vaporized during dissection and practical studying on cadaver. This study was designed to determine the histopathologic and morphometric changes of rat kidney while all of the experiments were exposed to formaldehyde for 18 weeks. 28 male albino Wistar rats were divided into the following three experimental groups (E1: 2hrs/d, 2d/w; E2: 2hrs/d, 4d/w; E3: 4hrs/d, 4d/w) and one control group (C). when the exposure period was expired the animals were anaesthetized with chloroform. After cervical dislocation, the abdomen was dissected and the kidneys were taken. The kidney specimens were sectioned and stained with Haematoxylin and Eosin technique for histologic and morphometric study. Data were...
Tipo: Journal article
Palavras-chave: Formaldehyde; Exposure; Histology; Kidney; Rat; Morphometry.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400037

Preventing Effect of Vitamin E on Oocytes Apoptosis in Morphine-treated Mice
Provedor de dados: 77
Autores: Asadi,Ebrahim; Shabani,Ronak; Ghafari,Soraya; Golalipour,Mohammad Jafar.
Several studies have shown that Morphine Sulfate affects on fertility, embryogenesis and consequent pregnancy loss and ultrastructural alterations of oocytes in animal model. This study was done to determine the effect of morphine sulfate on oocytes apoptosis and preventive role of daily supplementation of Vitamin E on oocytes apoptosis in morphine sulfate -treated mice. Twenty-four NMARI female mice were randomly allocated into four experimental groups. For 15 days, control group received saline (0.2 ml/day by subcutaneous injection), group I Vitamin E (60 mg/kg/day orally), group II Morphine Sulfate (10 mg/kg/day by subcutaneous injection) and group III Morphine Sulfate with Vitamin E (60 mg/kg/day orally). Then, animals were superovulated with PSMG (10...
Tipo: Journal article
Palavras-chave: Oocytes; Morphine sulfate; Vitamin E; Apoptosis; TUNEL assay; Mice.
Ano: 2013
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200029

Effect of Urtica dioica L Extract on Quantitative Morphometric Alterations of Liver Parenchymal Cells in STZ Diabetic Rats
Provedor de dados: 77
Autores: Golalipour,Mohammad Jafar; Ghafari,Soraya; Farsi,Mir Mehrdad.
Diabetes is associated with several structural and functional liver abnormalities that affect glycogen and lipid metabolism. In this study, an attempt was made to evaluate the effects of hydroalcoholic extract of Urtica dioica leaves on Quantitative morphometric changes in parenchymal cells of the livers in STZ diabetic rats. Thirty male Wistar rats were allocated in 3 groups: normal, diabetic and treatment. Hyperglycemia was induced by 80 mg/kg Streptozotocin intraperitoneally. One week after the injection of STZ, the third group received the hydroalcoholic extract of Urtica dioica at 100 mg/kg/day over four weeks. After five weeks, the animals were sacrificed and whole livers were removed. Liver specimens were used for quantitative morphometric analyze...
Tipo: Journal article
Palavras-chave: Diabetes; Urtica dioica; Liver; Hepatocyte; Morphometry.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400058

Ganglionic Cells Apoptosis in Retinal Layer of Rat Offspring due to Gestational Diabetes
Provedor de dados: 77
Autores: Najafdari,Simin; Rezaei,Noorallah; Shafaroodi,Majid Malekzadeh; Ghafari,Soraya; Golalipour,Mohammad Jafar.
Previous studies have shown the adverse effects of gestational diabetes on hippocampal neuronal density in animal models. This study was conducted to determine the effect of gestational diabetes on retinal ganglionic cell density, the thickness of the retinal layer and apoptotic ganglionic cell density in 28-day-old of rat offspring. In this experimental study, 10 Wistar rat dams were randomly allocated in control and diabetic groups. Gestational diabetes was induced by 40 mg/kg/body weight of streptozotocin at the first day of gestation, intraperitoneally, dams in control group received an equivalent volume normal saline. At postnatal day 28, six offspring of each gestational diabetes and controls were randomly selected, sacrificed and sections (6...
Tipo: Journal article
Palavras-chave: Gestational diabetes; Apoptosis; Retinal layer; Ganglionic cells; TUNEL Assay; Rat offspring.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000400001

Study of Embryotoxicity of Mentha piperita L. During Organogenesis in Balb/c Mice
Provedor de dados: 77
Autores: Golalipour,Mohammad Jafar; Ghafari,Soraya; Maleki,Alireza; Kiani,Mossa; Asadi,Ebrahim; Farsi,Mirmerhdad.
Mentha piperita (Labiatae), commonly known as peppermint is a native Iranian herb which is used in folk medicine for various purposes. This study was carried out to reveal the teratogenic effect of Mentha piperita on mice fetuses. In this experimental study, pregnant Balb/c mice divided to four groups. Case group received 600 (treatment I) and 1200 (treatment II) mg/kg/day the hydroalcoholic extract of Mentha piperita during 6-15 of gestational days and one control group received normal saline during GD6-GD15 by gavages and other control group did not receive any matter during 6-15 of gestational days. Mice sacrificed at GD18 and embryos were collected. Macroscopic observation was done by stereomicroscope. 20 fetuses of each group were stained by Alizarin...
Tipo: Journal article
Palavras-chave: Mentha piperita; Teratogen; Bone ossification; Developmental toxicity; Mice.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000300033