Consulta: creatorFacets:"Giese,N.A."
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Relationship of cytokines and cytokine signaling to immunodeficiency disorders in the mouse
Provedor de dados: 56
Autores: Morawetz,R.A.; Giese,N.A.; Gabriele,L.; Rothman,P.; Horak,I.; Ozato,K.; Morse III,H.C.
The contributions of cytokines to the development and progression of disease in a mouse model of retrovirus-induced immunodeficiency (MAIDS) are controversial. Some studies have indicated an etiologic role for type 2 cytokines, while others have emphasized the importance of type 1 cytokines. We have used mice deficient in expression of IL-4, IL-10, IL-4 and IL-10, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt;, or ICSBP - a transcriptional protein involved in IFN signaling - to examine their contributions to this disorder. Our results demonstrate that expression of type 2 cytokines is an epiphenomenon of infection and that IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; is a driving force in disease progression. In addition, exogenously administered IL-12...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ICSBP; Immunodeficiency; Interferon; MAIDS.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100008