Consulta: creatorFacets:"Grellier, Philippe"
Registros recuperados: 2
Data/hora: 06/06/2024 05:54:13

Deconjugated Bile Salts Produced by Extracellular Bile-Salt Hydrolase-Like Activities from the Probiotic Lactobacillus johnsonii La1 Inhibit Giardia duodenalis In vitro Growth
Provedor de dados: 5
Autores: Travers, Marie-agnes; Sow, Cisse; Zirah, Severine; Deregnaucourt, Christiane; Chaouch, Soraya; Queiroz, Rayner M. L.; Charneau, Sebastien; Allain, Thibault; Florent, Isabelle; Grellier, Philippe.
Giardiasis, currently considered a neglected disease, is caused by the intestinal protozoan parasite Giardia duodenalis and is widely spread in human as well as domestic and wild animals. The lack of appropriate medications and the spread of resistant parasite strains urgently call for the development of novel therapeutic strategies. Host microbiota or certain probiotic strains have the capacity to provide some protection against giardiasis. By combining biological and biochemical approaches, we have been able to decipher a molecular mechanism used by the probiotic strain Lactobacillus johnsonii La1 to prevent Giardia growth in vitro. We provide evidence that the supernatant of this strain contains active principle(s) not directly toxic to Giardia but able...
Tipo: Text
Palavras-chave: Giardiasis; Lactobacilli; Probiotics; Microbiota; Bile salts; Anti-giardial activity; Choloylglycine bile acid hydrolase.
Ano: 2016
URL: http://archimer.ifremer.fr/doc/00351/46211/45906.pdf

Bile Salt Hydrolase Activities: A Novel Target to Screen Anti-Giardia Lactobacilli?
Provedor de dados: 5
Autores: Allain, Thibault; Chaouch, Soraya; Thomas, Myriam; Travers, Marie-agnes; Valle, Isabelle; Langella, Philippe; Grellier, Philippe; Polack, Bruno; Florent, Isabelle; Bermudez-humaran, Luis G.
Giardia duodenalis is a protozoan parasite responsible for giardiasis, a disease characterized by intestinal malabsorption, diarrhea and abdominal pain in a large number of mammal species. Giardiasis is one of the most common intestinal parasitic diseases in the world and thus a high veterinary, and public health concern. It is wellestablished that some probiotic bacteria may confer protection against this parasite in vitro and in vivo and we recently documented the implication of bile-salt hydrolase (BSH)-like activities from strain La1 of Lactobacillus johnsonii as mediators of these effects in vitro. We showed that these activities were able to generate deconjugated bile salts that were toxic to the parasite. In the present study, a wide collection of...
Tipo: Text
Palavras-chave: Giardia duodenalis; Lactobacilli; Lactobacillus johnsonii; Lactobacillus gasseri; Probiotics; Bile salt hydrolases.
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00424/53569/54417.pdf