Consulta: creatorFacets:"Grunau, Christoph"
Registros recuperados: 23
Data/hora: 06/06/2024 05:55:11

Notos - a galaxy tool to analyze CpN observed expected ratios for inferring DNA methylation types
Provedor de dados: 5
Autores: Bulla, Ingo; Aliaga, Benoit; Lacal, Virginia; Bulla, Jan; Grunau, Christoph; Chaparro, Cristian.
Background: DNA methylation patterns store epigenetic information in the vast majority of eukaryotic species. The relatively high costs and technical challenges associated with the detection of DNA methylation however have created a bias in the number of methylation studies towards model organisms. Consequently, it remains challenging to infer kingdom-wide general rules about the functions and evolutionary conservation of DNA methylation. Methylated cytosine is often found in specific CpN dinucleotides, and the frequency distributions of, for instance, CpG observed/expected (CpG o/e) ratios have been used to infer DNA methylation types based on higher mutability of methylated CpG. Results: Predominantly model-based approaches essentially founded on...
Tipo: Text
Palavras-chave: Epigenetics; DNA methylation; Kernel density estimation; CpG o/e ratio; CpN o/e ratio.
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00437/54816/71790.pdf

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni
Provedor de dados: 5
Autores: Geyer, Kathrin K.; Niazi, Umar H.; Duval, David; Cosseau, Celine; Tomlinson, Chad; Chalmers, Iain W.; Swain, Martin T.; Cutress, David J.; Bickham-wright, Utibe; Munshi, Sabrina E.; Grunau, Christoph; Yoshino, Timothy P.; Hoffmann, Karl F.
Background The debilitating human disease schistosomiasis is caused by infection with schistosome parasites that maintain a complex lifecycle alternating between definitive (human) and intermediate (snail) hosts. While much is known about how the definitive host responds to schistosome infection, there is comparably less information available describing the snail's response to infection. Methodology/Principle findings Here, using information recently revealed by sequencing of the Biomphalaria glabrata intermediate host genome, we provide evidence that the predicted core snail DNA methylation machinery components are associated with both intra-species reproduction processes and inter-species interactions. Firstly, methyl-CpG binding domain protein...
Tipo: Text
Ano: 2017
URL: https://archimer.ifremer.fr/doc/00389/50000/71812.pdf

A simple ATAC-seq protocol for population epigenetics
Provedor de dados: 5
Autores: De Carvalho Augusto, Ronaldo; Rey, Oliver; Cosseau, Céline; Chaparro, Cristian; Vidal-dupiol, Jeremie; Allienne, Jean-françois; Duval, David; Pinaud, Silvain; Tönges, Sina; Andriantsoa, Ranja; Luquet, Emilien; Aubret, Fabien; Dia Sow, Mamadou; David, Patrice; Thomson, Vicki; Joly, Dominique; Gomes Lima, Mariana; Federico, Déborah; Danchin, Etienne; Minoda, Aki; Grunau, Christoph.
We describe here a protocol for the generation of sequence-ready libraries for population epigenomics studies, and the analysis of alignment results. We show that the protocol can be used to monitor chromatin structure changes in populations when exposed to environmental cues. The protocol is a streamlined version of the Assay for transposase accessible chromatin with high-throughput sequencing (ATAC-seq) that provides a positive display of accessible, presumably euchromatic regions. The protocol is straightforward and can be used with small individuals such as daphnia and schistosome worms, and probably many other biological samples of comparable size (~10,000 cells), and it requires little molecular biology handling expertise.
Tipo: Text
Palavras-chave: Epigenetics; Epigenomics; ATAC-seq; Daphnia pulex; Schistosoma mansoni.
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00681/79353/81859.pdf

Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response
Provedor de dados: 5
Autores: Vidal-dupiol, Jeremie; Dheilly, Nolwenn M.; Rondon, Rodolfo; Grunau, Christoph; Cosseau, Celine; Smith, Kristina M.; Freitag, Michael; Adjeroud, Mehdi; Mitta, Guillaume.
Global change and its associated temperature increase has directly or indirectly changed the distributions of hosts and pathogens, and has affected host immunity, pathogen virulence and growth rates. This has resulted in increased disease in natural plant and animal populations worldwide, including scleractinian corals. While the effects of temperature increase on immunity and pathogen virulence have been clearly identified, their interaction, synergy and relative weight during pathogenesis remain poorly documented. We investigated these phenomena in the interaction between the coral Pocillopora damicornis and the bacterium Vibrio coralliilyticus, for which the infection process is temperature-dependent. We developed an experimental model that enabled...
Tipo: Text
Ano: 2014
URL: http://archimer.ifremer.fr/doc/00221/33265/31738.pdf

Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni
Provedor de dados: 5
Autores: Roquis, David; Taudt, Aaron; Geyer, Kathrin K.; Padalino, Gilda; Hoffmann, Karl F.; Holroyd, Nancy; Berriman, Matt; Aliaga, Benoit; Chaparro, Cristian; Grunau, Christoph; De Carvalho Augusto, Ronaldo.
Epigenetic mechanisms and chromatin structure play an important role in development. Their impact is therefore expected to be strong in parasites with complex life cycles and multiple, strikingly different, developmental stages, i.e. developmental plasticity. Some studies have already described how the chromatin structure, through histone modifications, varies from a developmental stage to another in a few unicellular parasites. While H3K4me3 profiles remain relatively constant, H3K27 trimethylation and bivalent methylation show strong variation. Inhibitors (A366 and GSK343) of H3K27 histone methyltransferase activity in S. mansoni efficiently blocked miracidium to sporocyst transition indicating that H3K27 trimethylation is required for life cycle...
Tipo: Text
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00445/55690/71773.s001

Whole genome analysis of a schistosomiasis-transmitting freshwater snail
Provedor de dados: 5
Autores: Adema, Coen M.; Hillier, Ladeana W.; Jones, Catherine S.; Loker, Eric S.; Knight, Matty; Minx, Patrick; Oliveira, Guilherme; Raghavan, Nithya; Shedlock, Andrew; Do Amaral, Laurence Rodrigues; Arican-goktas, Halime D.; Assis, Juliana G.; Baba, Elio Hideo; Baron, Olga L.; Bayne, Christopher J.; Bickham-wright, Utibe; Biggar, Kyle K.; Blouin, Michael; Bonning, Bryony C.; Botka, Chris; Bridger, Joanna M.; Buckley, Katherine M.; Buddenborg, Sarah K.; Caldeira, Roberta Lima; Carleton, Julia; Carvalho, Omar S.; Castillo, Maria G.; Chalmers, Iain W.; Christensens, Mikkel; Clifton, Sandra; Cosseau, Celine; Coustau, Christine; Cripps, Richard M.; Cuesta-astroz, Yesid; Cummins, Scott F.; Di Stephano, Leon; Dinguirard, Nathalie; Duval, David; Emrich, Scott; Feschotte, Cedric; Feyereisen, Rene; Fitzgerald, Peter; Fronick, Catrina; Fulton, Lucinda; Galinier, Richard; Gava, Sandra G.; Geusz, Michael; Geyer, Kathrin K.; Giraldo-calderon, Gloria I.; Gomes, Matheus De Souza; Gordy, Michelle A.; Gourbal, Benjamin; Grunau, Christoph; Hanington, Patrick C.; Hoffmann, Karl F.; Hughes, Daniel; Humphries, Judith; Jackson, Daniel J.; Jannotti-passos, Liana K.; Jeremias, Wander De Jesus; Jobling, Susan; Kamel, Bishoy; Kapusta, Aurelie; Kaur, Satwant; Koene, Joris M.; Kohn, Andrea B.; Lawson, Dan; Lawton, Scott P.; Liang, Di; Limpanont, Yanin; Liu, Sijun; Lockyer, Anne E.; Lovato, Tyanna L.; Ludolf, Fernanda; Magrini, Vince; Mcmanus, Donald P.; Medina, Monica; Misra, Milind; Mitta, Guillaume; Mkoji, Gerald M.; Montague, Michael J.; Montelongo, Cesar; Moroz, Leonid L.; Munoz-torres, Monica C.; Niazi, Umar; Noble, Leslie R.; Oliveira, Francislon S.; Pais, Fabiano S.; Papenfuss, Anthony T.; Peace, Rob; Pena, Janeth J.; Pila, Emmanuel A.; Quelais, Titouan; Raney, Brian J.; Rast, Jonathan P.; Rollinson, David; Rosse, Izinara C.; Rotgans, Bronwyn; Routledge, Edwin J.; Ryan, Kathryn M.; Scholte, Larissa L. S.; Storey, Kenneth B.; Swain, Martin; Tennessen, Jacob A.; Tomlinson, Chad; Trujillo, Damian L.; Volpi, Emanuela V.; Walker, Anthony J.; Wang, Tianfang; Wannaporn, Ittiprasert; Warren, Wesley C.; Wu, Xiao-jun; Yoshino, Timothy P.; Yusuf, Mohammed; Zhang, Si-ming; Zhao, Min; Wilson, Richard K.
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of...
Tipo: Text
Ano: 2017
URL: https://archimer.ifremer.fr/doc/00387/49840/71816.pdf

Dosage Compensation throughout the Schistosoma mansoni Lifecycle: Specific Chromatin Landscape of the Z Chromosome
Provedor de dados: 5
Autores: Picard, Marion A. L.; Vicoso, Beatriz; Roquis, David; Bulla, Ingo; Augusto, Ronaldo C.; Arancibia, Nathalie; Grunau, Christoph; Boissier, Jerome; Cosseau, Celine.
Differentiated sex chromosomes are accompanied by a difference in gene dose between X/Z-specific and autosomal genes. At the transcriptomic level, these sex-linked genes can lead to expression imbalance, or gene dosage can be compensated by epigenetic mechanisms and results into expression level equalization. Schistosoma mansoni has been previously described as a ZW species (i.e., female heterogamety, in opposition to XY male heterogametic species) with a partial dosage compensation, but underlying mechanisms are still unexplored. Here, we combine transcriptomic (RNA-Seq) and epigenetic data (ChIP-Seq against H3K4me3, H3K27me3, and H4K20me1 histone marks) in free larval cercariae and intravertebrate parasitic stages. For the first time, we describe...
Tipo: Text
Palavras-chave: Dosage compensation; Chromatin landscape; Histone modifications; Female heterogamety; Schistosoma mansoni.
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00514/62580/66929.pdf

The Epigenetics Dilemma
Provedor de dados: 5
Autores: Grunau, Christoph; Le Luyer, Jeremy; Laporte, Martin; Joly, Dominique.
Tipo: Text
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00599/71139/69454.pdf

(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
Provedor de dados: 5
Autores: Cosseau, Celine; Wolkenhauer, Olaf; Padalino, Gilda; Geyer, Kathrin K.; Hoffmann, Karl F.; Grunau, Christoph.
The GxE concept, in which genotype x environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by 'inheritance system'. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.
Tipo: Text
Ano: 2017
URL: https://archimer.ifremer.fr/doc/00385/49607/71826.pdf

Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Provedor de dados: 5
Autores: Brown, Peter; Tan, Aik-choon; El-esawi, Mohamed A.; Liehr, Thomas; Blanck, Oliver; Gladue, Douglas P.; Almeida, Gabriel M. F.; Cernava, Tomislav; Sorzano, Carlos O.; Yeung, Andy W. K.; Engel, Michael S.; Chandrasekaran, Arun Richard; Muth, Thilo; Staege, Martin S.; Daulatabad, Swapna V.; Widera, Darius; Zhang, Junpeng; Meule, Adrian; Honjo, Ken; Pourret, Olivier; Yin, Cong-cong; Zhang, Zhongheng; Cascella, Marco; Flegel, Willy A.; Goodyear, Carl S.; Van Raaij, Mark J.; Bukowy-bieryllo, Zuzanna; Campana, Luca G.; Kurniawan, Nicholas A.; Lalaouna, David; Huttner, Felix J.; Ammerman, Brooke A.; Ehret, Felix; Cobine, Paul A.; Tan, Ene-choo; Han, Hyemin; Xia, Wenfeng; Mccrum, Christopher; Dings, Ruud P. M.; Marinello, Francesco; Nilsson, Henrik; Nixon, Brett; Voskarides, Konstantinos; Yang, Long; Costa, Vincent D.; Bengtsson-palme, Johan; Bradshaw, William; Grimm, Dominik G.; Kumar, Nitin; Martis, Elvis; Prieto, Daniel; Sabnis, Sandeep C.; Amer, Said E. D. R.; Liew, Alan W. C.; Perco, Paul; Rahimi, Farid; Riva, Giuseppe; Zhang, Chongxing; Devkota, Hari P.; Ogami, Koichi; Basharat, Zarrin; Fierz, Walter; Siebers, Robert; Tan, Kok-hian; Boehme, Karen A.; Brenneisen, Peter; Brown, James A. L.; Dalrymple, Brian P.; Harvey, David J.; Ng, Grace; Werten, Sebastiaan; Bleackley, Mark; Dai, Zhanwu; Dhariwal, Raman; Gelfer, Yael; Hartmann, Marcus D.; Miotla, Pawel; Tamaian, Radu; Govender, Pragashnie; Gurney-champion, Oliver J.; Kauppila, Joonas H.; Zhang, Xiaolei; Echeverria, Natalia; Subhash, Santhilal; Sallmon, Hannes; Tofani, Marco; Bae, Taeok; Bosch, Oliver; Cuiv, Paraic O.; Danchin, Antoine; Diouf, Barthelemy; Eerola, Tuomas; Evangelou, Evangelos; Filipp, Fabian V.; Klump, Hannes; Kurgan, Lukasz; Smith, Simon S.; Terrier, Olivier; Tuttle, Neil; Ascher, David B.; Janga, Sarath C.; Schulte, Leon N.; Becker, Daniel; Browngardt, Christopher; Bush, Stephen J.; Gaullier, Guillaume; Ide, Kazuki; Meseko, Clement; Werner, Gijsbert D. A.; Zaucha, Jan; Al-farha, Abd A.; Greenwald, Noah F.; Popoola, Segun I.; Rahman, Md Shaifur; Xu, Jialin; Yang, Sunny Y.; Hiroi, Noboru; Alper, Ozgul M.; Baker, Chris I.; Bitzer, Michael; Chacko, George; Debrabant, Birgit; Dixon, Ray; Forano, Evelyne; Gilliham, Matthew; Kelly, Sarah; Klempnauer, Karl-heinz; Lidbury, Brett A.; Lin, Michael Z.; Lynch, Iseult; Ma, Wujun; Maibach, Edward W.; Mather, Diane E.; Nandakumar, Kutty S.; Ohgami, Robert S.; Parchi, Piero; Tressoldi, Patrizio; Xue, Yu; Armitage, Charles; Barraud, Pierre; Chatzitheochari, Stella; Coelho, Luis P.; Diao, Jiajie; Doxey, Andrew C.; Gobet, Angelique; Hu, Pingzhao; Kaiser, Stefan; Mitchell, Kate M.; Salama, Mohamed F.; Shabalin, Ivan G.; Song, Haijun; Stevanovic, Dejan; Yadollahpour, Ali; Zeng, Erliang; Zinke, Katharina; Alimba, C. G.; Beyene, Tariku J.; Cao, Zehong; Chan, Sherwin S.; Gatchell, Michael; Kleppe, Andreas; Piotrowski, Marcin; Torga, Gonzalo; Woldesemayat, Adugna A.; Cosacak, Mehmet I.; Haston, Scott; Ross, Stephanie A.; Williams, Richard; Wong, Alvin; Abramowitz, Matthew K.; Effiong, Andem; Lee, Senhong; Abid, Muhammad Bilal; Agarabi, Cyrus; Alaux, Cedric; Albrecht, Dirk R.; Atkins, Gerald J.; Beck, Charles R.; Bonvin, A. M. J. J.; Bourke, Emer; Brand, Thomas; Braun, Ralf J.; Bull, James A.; Cardoso, Pedro; Carter, Dee; Delahay, Robin M.; Ducommun, Bernard; Duijf, Pascal H. G.; Epp, Trevor; Eskelinen, Eeva-liisa; Fallah, Mazyar; Farber, Debora B.; Fernandez-triana, Jose; Feyerabend, Frank; Florio, Tullio; Friebe, Michael; Furuta, Saori; Gabrielsen, Mads; Gruber, Jens; Grybos, Malgorzata; Han, Qian; Heinrich, Michael; Helantera, Heikki; Huber, Michael; Jeltsch, Albert; Jiang, Fan; Josse, Claire; Jurman, Giuseppe; Kamiya, Haruyuki; De Keersmaecker, Kim; Kristiansson, Erik; De Leeuw, Frank-erik; Li, Jiuyong; Liang, Shide; Lopez-escamez, Jose A.; Lopez-ruiz, Francisco J.; Marchbank, Kevin J.; Marschalek, Rolf; Martin, Carmen S.; Miele, Adriana E.; Montagutelli, Xavier; Morcillo, Esteban; Nicoletti, Rosario; Niehof, Monika; O'Toole, Ronan; Ohtomo, Toshihiko; Oster, Henrik; Palma, Jose-alberto; Paterson, Russell; Peifer, Mark; Portilla, Maribel; Portillo, M. C.; Pritchard, Antonia L.; Pusch, Stefan; Raghava, Gajendra P. S.; Roberts, Nicola J.; Ross, Kehinde; Schuele, Birgitt; Sergeant, Kjell; Shen, Jun; Stella, Alessandro; Sukocheva, Olga; Uversky, Vladimir N.; Vanneste, Sven; Villet, Martin H.; Viveiros, Miguel; Vorholt, Julia A.; Weinstock, Christof; Yamato, Masayuki; Zabetakis, Ioannis; Zhao, Xin; Ziegler, Andreas; Aizat, Wan M.; Atlas, Lauren; Bridges, Kristina M.; Chakraborty, Sayan; Deschodt, Mieke; Domingues, Helena S.; Esfahlani, Shabnam S.; Falk, Sebastian; Guisado, J. L.; Kane, Nolan C.; Kueberuwa, Gray; Lau, Colleen L.; Liang, Dai; Liu, Enwu; Luu, Andreas M.; Ma, Chuang; Ma, Lisong; Moyer, Robert; Norris, Adam D.; Panthee, Suresh; Parsons, Jerod R.; Peng, Yousong; Pinto, Ines Mendes; Reschke, Cristina R.; Sillanpaa, Elina; Stewart, Christopher J.; Uhle, Florian; Yang, Hui; Zhou, Kai; Zhu, Shu; Ashry, Mohamed; Bergsland, Niels; Berthold, Maximilian; Chen, Chang-er; Colella, Vito; Cuypers, Maarten; Eskew, Evan A.; Fan, Xiao; Gajda, Maksymilian; Gonzalezlez-prendes, Rayner; Goodin, Amie; Graham, Emily B.; Groen, Ewout J. N.; Gutierrez-sacristan, Alba; Habes, Mohamad; Heffler, Enrico; Higginbottom, Daniel B.; Janzen, Thijs; Jayaraman, Jayakumar; Jibb, Lindsay A.; Jongen, Stefan; Kinyanjui, Timothy; Koleva-kolarova, Rositsa G.; Li, Zhixiu; Liu, Yu-peng; Lund, Bjarte A.; Lussier, Alexandre A.; Ma, Liping; Mier, Pablo; Moore, Matthew D.; Nagler, Katja; Orme, Mark W.; Pearson, James A.; Prajapati, Anilkumar S.; Saito, Yu; Troder, Simon E.; Uchendu, Florence; Verloh, Niklas; Voutchkova, Denitza D.; Abu-zaid, Ahmed; Bakkach, Joaira; Baumert, Philipp; Dono, Marcos; Hanson, Jack; Herbelet, Sandrine; Hobbs, Emma; Kulkarni, Ameya; Kumar, Narendra; Liu, Siqi; Loft, Nikolai D.; Reddan, Tristan; Senghore, Thomas; Vindin, Howard; Xu, Haotian; Bannon, Ross; Chen, Branson; Cheung, Johnny T. K.; Cooper, Jeffrey; Esnakul, Ashwini K.; Feghali, Karine A.; Ghelardi, Emilia; Gnasso, Agostino; Horbar, Jeffrey; Lai, Hei M.; Li, Jian; Ma, Lan; Ma, Ruiyan; Pan, Zihang; Peres, Marco A.; Pranata, Raymond; Seow, Esmond; Sydes, Matthew; Testoni, Ines; Westermair, Anna L.; Yang, Yongliang; Afnan, Masoud; Albiol, Joan; Albuquerque, Lucia G.; Amiya, Eisuke; Amorim, Rogerio M.; An, Qianli; Andersen, Stig U.; Aplin, John D.; Argyropoulos, Christos; Asmann, Yan W.; Assaeed, Abdulaziz M.; Atanasov, Atanas G.; Atchison, David A.; Avery, Simon V.; Avillach, Paul; Baade, Peter D.; Backman, Lars; Badie, Christophe; Baldi, Alfonso; Ball, Elizabeth; Bardot, Olivier; Barnett, Adrian G.; Basner, Mathias; Batra, Jyotsna; Bazanova, O. M.; Beale, Andrew; Beddoe, Travis; Bell, Melanie L.; Berezikov, Eugene; Berners-price, Sue; Bernhardt, Peter; Berry, Edward; Bessa, Theolis B.; Billington, Craig; Birch, John; Blakely, Randy D.; Blaskovich, Mark A. T.; Blum, Robert; Boelaert, Marleen; Bogdanos, Dimitrios; Bosch, Carles; Bourgoin, Thierry; Bouvard, Daniel; Boykin, Laura M.; Bradley, Graeme; Braun, Daniel; Brownlie, Jeremy; Bruhl, Albert; Burt, Austin; Butler, Lisa M.; Byrareddy, Siddappa N.; Byrne, Hugh J.; Cabantous, Stephanie; Calatayud, Sara; Candal, Eva; Carlson, Kimberly; Casillas, Sonia; Castelvetro, Valter; Caswell, Patrick T.; Cavalli, Giacomo; Cerovsky, Vaclav; Chagoyen, Monica; Chen, Chang-shi; Chen, Dong F.; Chen, Hao; Chen, Hui; Chen, Jui-tung; Chen, Yinglong; Cheng, Changxiu; Cheng, Jianlin; Chinapaw, Mai; Chinopoulos, Christos; Cho, William C. S.; Chong, Lillian; Chowdhury, Debashish; Chwalibog, Andre; Ciresi, A.; Cockcroft, Shamshad; Conesa, Ana; Cook, Penny A.; Cooper, David N.; Coqueret, Olivier; Corea, Enoka M.; Costa, Elisio; Coupland, Carol; Crawford, Stephanie Y.; Cruz, Aparecido D.; Cui, Huijuan; Cui, Qiang; Culver, David C.; D'Angiulli, Amedeo; Dahms, Tanya E. S.; Daigle, France; Dalgleish, Raymond; Danielsen, Havard E.; Darras, Sebastien; Davidson, Sean M.; Day, David A.; Degirmenci, Volkan; Demaison, Luc; Devriendt, Koenraad; Ding, Jiandong; Dogan, Yunus; Dong, X. C.; Donner, Claudio F.; Dressick, Walter; Drevon, Christian A.; Duan, Huiling; Ducho, Christian; Dumaz, Nicolas; Dwarakanath, Bilikere S.; Ebell, Mark H.; Eisenhardt, Steffen; Elkum, Naser; Engel, Nadja; Erickson, Timothy B.; Fairhead, Michael; Faville, Marty J.; Fejzo, Marlena S.; Festa, Fernanda; Feteira, Antonio; Flood-page, Patrick; Forsayeth, John; Fox, Simon A.; Franks, Steven J.; Frentiu, Francesca D.; Frilander, Mikko J.; Fu, Xinmiao; Fujita, Satoshi; Galea, Ian; Galluzzi, Luca; Gani, Federica; Ganpule, Arvind P.; Garcia-alix, Antonio; Gedye, Kristene; Giordano, Maurizio; Giunta, Cecilia; Gleeson, Paul A.; Goarant, Cyrille; Gong, Haipeng; Gora, Diop; Gough, Michael J.; Goyal, Ravinder; Graham, Kathryn E.; Grande-perez, Ana; Graves, Patricia M.; Greidanus, Harm; Grice, Darren; Grunau, Christoph; Gumulya, Yosephine; Guo, Yabin; Gurevich, Vsevolod V.; Gusev, Oleg; Hacker, Elke; Hage, Steffen R.; Hagen, Guy; Hahn, Steven; Haller, Dagmar M.; Hammerschmidt, Sven; Han, Jianwei; Han, Renzhi; Handfield, Martin; Hapuarachchi, Hapuarachchige C.; Harder, Timm; Hardingham, Jennifer E.; Heck, Michelle; Heers, Marcel; Hew, Khe F.; Higuchi, Yohei; St Hilaire, Cynthia; Hilton, Rachel; Hodzic, Enisa; Hone, Andrew; Hongoh, Yuichi; Hu, Guoku; Huber, Heinz P.; Hueso, Luis E.; Huirne, Judith; Hurt, Lisa; Idborg, Helena; Ikeo, Kazuho; Ingley, Evan; Jakeman, Philip M.; Jensen, Arne; Jia, Hong; Jia, Husen; Jia, Shuqin; Jiang, Jianping; Jiang, Xingyu; Jin, Yi; Jo, Daehyun; Johnson, Andrew M.; Johnston, Marie; Jonscher, Karen R.; Jorens, Philippe G.; Jorgensen, Jens O. L.; Joubert, Johan W.; Jung, Sin-ho; Junior, Antonio M.; Kahan, Thomas; Kamboj, Sunjeev K.; Kang, Yong-kook; Karamanos, Yannis; Karp, Natasha A.; Kelly, Ryan; Kenna, Ralph; Kennedy, Jonathan; Kersten, Birgit; Khalaf, Roy A.; Khalid, Javaria M.; Khatlani, T.; Khider, Tarig; Kijanka, Gregor S.; King, Sarah R. B.; Kluz, Tomasz; Knox, Paul; Kobayashi, Tatsuya; Koch, Karl-wilhelm; Kohonen-corish, Maija R. J.; Kong, Xiangpeng; Konkle-parker, Deborah; Korpela, Kalevi M.; Kostrikis, Leondios G.; Kraiczy, Peter; Kratz, Harald; Krause, Gunter; Krebsbach, Paul H.; Kristensen, Soren R.; Kumari, Prerna; Kunimatsu, Akira; Kurdak, Hatice; Kwon, Young D.; Lachat, Carl; Lagisz, Malgorzata; Laky, Brenda; Lammerding, Jan; Lange, Matthias; Larrosa, Mar; Laslett, Andrew L.; Leclair, Elizabeth E.; Lee, Kyung-woo; Lee, Ming-yih; Lee, Moon-soo; Li, Genyuan; Li, Jiansheng; Lieb, Klaus; Lim, Yau Y.; Lindsey, Merry L.; Line, Paul-dag; Liu, Dengcai; Liu, Fengbin; Liu, Haiyan; Liu, Hongde; Lloyd, Vett K.; Lo, Te-wen; Locci, Emanuela; Loidl, Josef; Lorenzen, Johan; Lorkowski, Stefan; Lovell, Nigel H.; Lu, Hua; Lu, Wei; Lu, Zhiyong; Luengo, Gustavo S.; Lundh, Lars-gunnar; Lysy, Philippe A.; Mabb, Angela; Mack, Heather G.; Mackey, David A.; Mahdavi, S. R.; Maher, Pamela; Maher, Toby; Maity, Sankar N.; Malgrange, Brigitte; Mamoulakis, Charalampos; Mangoni, Arduino A.; Manke, Thomas; Manstead, Antony S. R.; Mantalaris, Athanasios; Marsal, Jan; Marschall, Hanns-ulrich; Martin, Francis L.; Martinez-raga, Jose; Martinez-salas, Encarnacion; Mathieu, Daniel; Matsui, Yoichi; Maza, Elie; Mccutcheon, James E.; Mckay, Gareth J.; Mcmillan, Brian; Mcmillan, Nigel; Meads, Catherine; Medina, Loreta; Merrick, B. Alex; Metzger, Dennis W.; Meunier, Frederic A.; Michaelis, Martin; Micheau, Olivier; Mihara, Hisaaki; Mintz, Eric M.; Mizukami, Takuo; Moalic, Yann; Mohapatra, D. P.; Monteiro, Antonia; Montes, Matthieu; Moran, John V.; Morozov, Sergey Y.; Mort, Matthew; Murai, Noriyuki; Murphy, Denis J.; Murphy, Susan K.; Murray, Shauna A.; Naganawa, Shinji; Nammi, Srinivas; Nasios, Grigorios; Natoli, Roman M.; Nguyen, Frederique; Nicol, Christine; Van Nieuwerburgh, Filip; Nilsen, Erlend B.; Nobile, Clarissa J.; O'Mahony, Margaret; Ohlsson, Sophie; Olatunbosun, Oluremi; Olofsson, Per; Ortiz, Alberto; Ostrikov, Kostya; Otto, Siegmar; Outeiro, Tiago F.; Ouyang, Songying; Paganoni, Sabrina; Page, Andrew; Palm, Christoph; Paradies, Yin; Parsons, Michael H.; Parsons, Nick; Pascal, Pigny; Paul, Elisabeth; Peckham, Michelle; Pedemonte, Nicoletta; Pellizzon, Michael A.; Petrelli, M.; Pichugin, Alexander; Pinto, Carlos J. C.; Plevris, John N.; Pollesello, Piero; Polz, Martin; Ponti, Giovanna; Porcelli, Piero; Prince, Martin; Quinn, Gwendolyn P.; Quinn, Terence J.; Ramula, Satu; Rappsilber, Juri; Rehfeldt, Florian; Reiling, Jan H.; Remacle, Claire; Rezaei, Mohsen; Riddick, Eric W.; Ritter, Uwe; Roach, Neil W.; Roberts, David D.; Robles, Guillermo; Rodrigues, Tiago; Rodriguez, Cesar; Roislien, Jo; Roobol, Monique J.; Rowe, J. Alexandra; Ruepp, Andreas; Van Ruitenbeek, Jan; Rust, Petra; Saad, Sonia; Sack, George H.; Santos, Manuela; Saudemont, Aurore; Sava, Gianni; Schrading, Simone; Schramm, Alexander; Schreiber, Martin; Schuler, Sidney; Schymkowitz, Joost; Sczyrba, Alexander; Seib, Kate L.; Shi, Han-ping; Shimada, Tomohiro; Shin, Jeon-soo; Shortt, Colette; Silveyra, Patricia; Skinner, Debra; Small, Ian; Smeets, Paul A. M.; So, Po-wah; Solano, Francisco; Sonenshine, Daniel E.; Song, Jiangning; Southall, Tony; Speakman, John R.; Srinivasan, Mandyam V.; Stabile, Laura P.; Stasiak, Andrzej; Steadman, Kathryn J.; Stein, Nils; Stephens, Andrew W.; Stewart, Douglas I.; Stine, Keith; Storlazzi, Curt; Stoynova, Nataliya V.; Strzalka, Wojciech; Suarez, Oscar M.; Sultana, Taranum; Sumant, Anirudha V.; Summers, Mathew J.; Sun, Gang; Tacon, Paul; Tanaka, Kozo; Tang, Haixu; Tanino, Yoshinori; Targett-adams, Paul; Tayebi, Mourad; Tayyem, Reema; Tebbe, Christoph C.; Telfer, Evelyn E.; Tempel, Wolfram; Teodorczyk-injeyan, Julita A.; Thijs, Gert; Thorne, Sally; Thrift, Amanda G.; Tiffon, Celine; Tinnefeld, Philip; Tjahjono, Daryono H.; Tolle, Fabrice; Toth, Ervin; Del Tredici, Andria L.; Tsapas, Apostolos; Tsirigotis, Konstantinos; Turak, Ayse; Tzotzos, George; Udo, Edet E.; Utsumi, Toshiaki; Vaidyanathan, Subramanian; Vaillant, Michel; Valsesia, Armand; Vandenbroucke, Roosmarijn E.; Veiga, Feliciano H.; Vendrell, Marc; Vesk, Peter A.; Vickers, Paul; Victor, Victor M.; Villemur, Richard; Vohl, Marie-claude; Voolstra, Christian R.; Vuillemin, Anne; Wakelin, Steven; Waldron, Levi; Walsh, Laurence J.; Wang, Amanda Y.; Wang, Fuan; Wang, Yun; Watanabe, Yoichi; Weigert, Andreas; Wen, Jet-chau; Wham, Carol; White, Ethan P.; Wiener, Jan; Wilharm, Gottfried; Wilkinson, Simon; Willmann, Raffaella; Wilson, Coralie; Wirth, Brunhilde; Wojan, Timothy R.; Wolff, Mathieu; Wong, Bryan M.; Wu, Tzu-wei; Wuerbel, Hanno; Xiao, Xiangshu; Xu, Dong; Xu, J. 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W.; Bijleveld, Erik; Bittner, Florian; Blombach, Fabian; Van Den Bos, Wouter; Boudreau, Shellie A.; Bramoweth, Adam D.; Braubach, Oliver; Cai, Yufeng; Campbell, Matthew; Cao, Zanxia; Catry, Thibault; Chen, Xin; Cheng, Shuiqin; Chung, Hee-jung; Chavez-fumagalli, Miguel A.; Conway, Aaron; Costa, Bruno M.; Cyr, Normand; Dean, Lorraine T.; Denzel, Martin S.; Dlamini, S. V.; Dudley, Kevin J.; Dufies, Maeva; Ecke, Thorsten; Eckweiler, Denitsa; Eixarch, Elisenda; El-adawy, Hosny; Emmrich, Julius V.; Eustace, Alex J.; Falter-wagner, Christine M.; Fuss, Johannes; Gao, Jianzhao; Gill, Martin R.; Gloyn, Liz; Goggs, Robert; Govinden, Usha; Greene, Garrett; Greiff, Victor; Grundle, D. S.; Gruneberg, Patrick; Gumede, Nicksy; Haore, Gbaguidi; Harrison, Pille; Hoenner, Xavier; Hojsgaard, Diego; Hori, Hikaru; Ikonomopoulou, Maria P.; Jeurissen, Patrick; Johnson, Daniel M.; Kabra, Dhiraj; Kamagata, Koji; Karmakar, Chandan; Kasian, Olga; Kaye, Linda K.; Khan, Murad M.; Kim, Yong-min; Kish, J. K.; Kobold, Sebastian; Kohanbash, Gary; Kohls, Gregor; Kugler, Jan-michael; Kumar, Gyanendra; Lacy-colson, Jon; Latif, Asam; Lauschke, Volker M.; Li, Bingling; Lim, Chinten J.; Liu, Fang; Liu, Xiaodong; Lu, Jin-jian; Lu, Qiang; Mahavadi, Poornima; Marzocchi, Ugo; Mcgarrigle, Christine A.; Van Meerten, Tom; Min, Rogier; Moal, Iain; Molari, Massimiliano; Molleman, Lucas; Mondal, Saiful R.; Van De Mortel, Thea; Moss, W. 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P.; Takeuchi, Hisashi; Tanadini-lang, S.; Tang, Fei; Tao, Wanyin; Theron, G.; Tian, Chang F.; Tian, Yu-shi; Tuttle, Lisa M.; Valenti, Anna; Verlot, Pierre; Walker, Mirella; Wang, Jun; Welter, Danielle; Winslade, Matthew; Wu, Dalei; Wu, Yi-rui; Xiao, Han; Xu, Beisi; Xu, Juan; Xu, Ziyue; Yang, Dongdong; Yang, Mingjun; Yankilevich, Patricio; You, Yuyi; Yu, Chenglong; Zhan, Jian; Zhang, Gong; Zhang, Kai; Zhang, Tuo; Zhang, Yi; Zhao, Guoyan; Zhao, Jing; Zhou, Xiaofan; Zhu, Zhenxing; Ajani, Penelope A.; Anazodo, Udunna C.; Bagloee, Saeed A.; Bail, Kasia; Bar, Ido; Bathelt, Joe; Benkeser, David; Bernier, Meghan L.; Blanchard, Adam M.; Boakye, Dominic W.; Bonatsos, Vasileios; Boon, Michele H.; Bouboulis, George; Bromfield, Elizabeth; Brown, Joshua; Bul, Kim C. M.; Burton, Kathryn J.; Butkowski, Eugene G.; Carroll, Grace; Chao, Fengqing; Charrier, Elisabeth E.; Chen, Xiaoyin; Chen, Yu-chih; Chenguang,; Choi, Jane R.; Christoffersen, Tore; Comel, Joao C.; Cosse, Cyril; Cui, Yanru; Van Dessel, Pieter; Dhaval,; Diodato, Daria; Duffey, Maelle; Dutt, Avik; Egea, Luis G.; El-said, Mohammed; Faye, Martin; Fernandez-fernandez, Beatriz; Foley, Kieran G.; Founou, Luria L.; Fu, Fan; Gadelkareem, Rabea A.; Galimov, Evgeny; Garip, Gulcan; Gemmill, Alison; Gouil, Quentin; Grey, James; Gridneva, Zoya; Grothe, Michel J.; Grebert, Theophile; Guerrero, Fabricio; Guignard, Leo; Haenssgen, Marco J.; Hasler, David; Holgate, Joan Y.; Huang, Ancheng; Hulse-kemp, Amanda M.; Jean-quartier, Claire; Jeon, Sang-min; Jia, Yangyang; Jutzeler, Catherine; Kalatzis, Panagiotis; Karim, Masud; Karsay, Kathrin; Keitel, Anne; Kempe, Andreas; Keown, Jeremy R.; Khoo, Chin M.; Khwaja, Nyil; Kievit, Rogier A.; Kosanic, Aleksandra; Koutoukidis, Dimitrios A.; Kramer, Paul; Kumar, Dilip; Kirag, Nukhet; Lanza, Giuseppe; Le, Thuc D.; Leem, Jung W.; Leightley, Daniel; Leite, Andreia; Lercher, Lukas; Li, Ying; Lim, Renly; Lima, Luiz R. A.; Lin, Li; Ling, Tong; Liu, Yuchen; Liu, Zhonghua; Lu, Yao; Lum, Fok M.; Luo, Hang; Machhi, Jatin; Macleod, Angus; Macwan, Isaac; Madala, Hanumantha R.; Madani, Nima; De Maio, Nicola; Makowiecki, Kalina; Mallinson, Daniel J.; Margelyte, Ruta; Maria, Caracausi; Markonis, Y.; Marsili, Luca; Mavoa, Suzanne; Mcwilliams, Lorna; Megersa, Moa; Mendes, Caetano S. M.; Menichetti, Julia; Mercieca-bebber, Rebecca; Miller, Jack J.; Minde, David-paul M.; Minges, Alexander; Mishra, Eleanor; Mishra, Virendra R.; Moores, Carly; Morrice, Nicola; Moskalensky, Alexander E.; Navarin, Nicolo; Negera, Edessa; Nolet, Philippe; Nordberg, Ana; Norden, Rickard; Nowicki, Jessica P.; Olova, Nelly; Olszewski, Pawel; Onzima, Robert; Pan, Chih-long; Park, Charny; Park, Dong Ik; Park, Seyoung; Patil, Chandrashekhar D.; Pedro, Sansoa A.; Perry, Samuel R.; Peter, Jessica; Peterson, Brent M.; Pezzuolo, Andrea; Pozdnyakov, Ilya; Qian, Siyu; Qin, Lei; Rafe, Ali; Raote, Ishier; Raza, Ali; Rebl, Henrike; Refai, Osama; Regan, Tim; Richa, Tambi; Richardson, Mark F.; Robinson, K. R.; Rossoni, Luca; Rouet, Romain; Safaei, Soroush; Schneeberger, Pierre H. H.; Schwotzer, Daniela; Sebastian, Agata; Selinski, Jennifer; Seltmann, Stefanie; Sha, Feng; Shalev, Nir; Shang, Jin-long; Singer, Josef; Singh, Mandeep; Smith, Taylor; Solomon-moore, Emma; Song, Lijuan; Soraggi, Samuele; Stanley, Ryan; Steckhan, Nico; Strobl, Frederic; Subissi, Lorenzo; Supriyanto, Irwan; Surve, Chinmay R.; Suzuki, Tomo; Syme, Caitlin; Sorelius, Karl; Tang, Young; Tantawy, Marwa; Tennakoon, Sumudu; Teseo, Serafino; Toelzer, Christine; Tomov, Nikola; Tovar, Miguel; Tran, Linh; Tripathi, Sushil; Tuladhar, Anil M.; Ukubuiwe, Azubuike C.; Ung, Carolina O. L.; Valgepea, Kaspar; Vatanparast, Hamid; Vidal, Arnau; Wang, Fang; Wang, Qing; Watari, Ricky; Webster, Rebecca; Webster, Ruth; Wei, Junnian; Wibowo, David; Wingenbach, Tanja S. H.; Xavier, Rose M.; Xiao, Shumin; Xiong, Peng; Xu, Shicai; Xu, Shilin; Yao, Ruifeng; Yao, Wen; Yin, Qinan; Yu, Yongbo; Zaitsu, Masayoshi; Zeineb, Zian; Zhan, Xiao-yong; Zhang, Jilei; Zhang, Rongqiang; Zhang, Wei; Zhang, Xianglilan; Zheng, Shan; Zhou, Bailing; Zhou, Xiaoyan; Ahmad, Haroon; Akinwumi, Sayo A.; Albery, Gregory F.; Alhowimel, Ahmed; Ali, Junaid; Alshehri, Mansour; Alsuhaibani, Mohammed; Anikin, Andrey; Azubuike, Samuel O.; Bach-mortensen, Anders; Baltiansky, Lior; Bartas, Martin; Belachew, Kiflemariam Y.; Bhardwaj, Vivek; Binder, Karin; Bland, Nicholas S.; Boah, Michael; Bullen, Benjamin; Calabro, Giovanna E.; Callahan, Tiffany J.; Cao, Bing; Chalmers, Kelsey; Chang, Wei; Che, Zhengping; Chen, Andrew T. Y.; Chen, Haimin; Chen, Huaming; Chen, Youning; Chen, Zhao; Choi, Youngrok; Chowdhury, Mohiuddin A. K.; Christensen, Martin R.; Cooke, Robert S. C.; Cottini, Marzia; Covington, Natalie V.; Cunningham, Catriona; Delarocque, Julien; Devos, Lucie; Dhar, Aurup R.; Ding, Ke-feng; Dong, Kexian; Dong, Zheng; Dreyer, Niklas; Ekstrand, Chelsea; Fardet, Tanguy; Feleke, Berhanu E.; Feurer, Thomas; Freitas, Angela; Gao, Tian; Asefa, N. G.; Giganti, Francesco; Grabowski, Piotr; Guerra-mora, Jose R.; Guo, Chengying; Guo, Xinyi; Gupta, Himanshu; He, Shuonan; Heijne, Marloes; Heinemann, Stephanie; Hogrebe, Alexander; Huang, Zhengping; Iskander-rizk, Sophinese; Iyer, Lavanya M.; Jahan, Yasmin; James, Ameh S.; Joel, Emmanuel; Joffroy, Bastian; Jegousse, Clara; Kambondo, George; Karnati, Priyanka; Kaya, Cihan; Ke, An; Kelly, Daniel; Kickert, Rob; Kidibule, Peter E.; Kieselmann, Jennifer P.; Kim, Hyeon J.; Kitazawa, Takeshi; Lamberts, Aniek; Li, You; Liang, Huakang; Linn, Sabrina N.; Litfin, Thomas; Liusuo, Wang; Lygirou, Vasiliki; Mahato, Ajay K.; Mai, Zhi-ming; Major, Rupert W.; Mali, Samira; Mallis, Panagiotis; Mao, Wenzhi; Mao, Wenzhi; Marvin-dowle, Katie; Marvin-dowle, Katie; Mason, Leanda D.; Merideth, Ben; Merino-plaza, Maria J.; Merlaen, Britt; Messina, Rossella; Mishra, Anand K.; Muhammad, Junaid; Musinguzi, Conrad; Nanou, Afroditi; Naqash, Amreen; Nguyen, Joe T.; Nguyen, Thi T. H.; Ni, Duan; Nida,; Notcovich, Shirli; Ohst, Barnabas; Ollivier, Quinn R.; Osses, Daniel F.; Peng, Xiangda; Plantinga, Arnoud; Pulia, Michael; Rafiq, Muhammad; Raman, Ayush; Raucher-chene, Delphine; Rawski, Rafal; Ray, Asit; Razak, Lubna A.; Rudolf, Kevin; Rusch, Peter; Sadoine, Margaux L.; Schmidt, Axel; Schurr, Roey; Searles, Stephen; Sharma, Saurab; Sheehan, Barry; Shi, Chunhu; Shohayeb, Belal; Sommerlad, Andrew; Strehlow, Jan; Sun, Xianbao; Sundar, Raghav; Taherzadeh, Ghazaleh; Tahir, Nur D. M.; Tang, Jun; Testa, Jean; Tian, Zhiqi; Tingting, Qian; Verheijen, Geert P.; Vickstrom, Casey; Wang, Teng; Wang, Xiaomin; Wang, Zhenxing; Wei, Pan; Wilson, Alex; Wyart,; Yassine, Abdul-amir; Yousefzadeh, Abbas; Zare, Asma; Zeng, Zhen; Zhang, Chengrong; Zhang, Haowen; Zhang, Linxing; Zhang, Tongchuan; Zhang, Weijia; Zhang, Zhe; Zhou, Jianyu; Zhu, Dongjie; Adamo, Vincenzo; Adeyemo, Adebolajo A.; Aggelidou, Maria; Al-owaifeer, Adi M.; Al-riyami, Arwa Z.; Alzghari, Saeed K.; Andersen, Vibeke; Angus, Kathryn; Asaduzzaman, Muhammad; Asady, Hadi; Ato, Dai; Bai, Xiaoyong; Baines, Rebecca L.; Ballantyne, Maghan; Ban, Bo; Beck, Jill; Ben-nafa, Walid; Black, Emma; Blancher, Antoine; Blankstein, Ron; Bodagh, Neil; Borges, Paulo A. V.; Brooks, Anastasia; Brox-ponce, Josue; Brunetti, Arturo; Canham, Colin D.; Carninci, Piero; Carvajal, Richard; Chang, Shun C.; Chao, Jie; Chatterjee, Pranab; Chen, He; Chen, Yi-chun; Chhatriwalla, Adnan K.; Chikowe, Ibrahim; Chuang, Trees-juen; Collevatti, Rosane G.; Valera-cornejo, Diego A.; Cuenda, Ana; Dao, Myriam; Dauga, Delphine; Deng, Zaian; Devkota, Kiran; Doan, Lisa V.; Elewa, Yaser H. A.; Fan, Dongsheng; Faruk, Mohammed; Feifei, Shi; Ferguson, Trevor S.; Fleres, Francesco; Foster, Emma J.; Foster, C. Stephen; Furer, Tzvi; Gao, Yibo; Garcia-rivera, Enid J.; Gazdar, Adi; George, Ronald B.; Ghosh, Sayantan; Gianchecchi, Elena; Gleason, Joshua M.; Hackshaw, Allan; Hall, Adam; Hall, Richard; Harper, Paul; Hogg, William E.; Huang, Guangqun; Hunter, Kylie E.; Ijzerman, Adriaan P.; Jesus, Carlos; Jian, Gao; Lewis, James S., Jr.; Kanj, Souha S.; Kaur, Harsheen; Kelly, Shona; Kheir, Fayez; Kichatova, V. S.; Kiyani, Musa; Klein, Reinhild; Kovesi, Tom; Kraschnewski, Jennifer L.; Kumar, Addanki P.; Labutin, Dmitry; Lazo-langner, Alejandro; Leclercq, Guy; Li, Maoteng; Li, Qingchun; Li, Tangliang; Li, Yongzhe; Liao, Wei-ting; Liao, Zheng-yin; Lin, Jessica; Lizer, J.; Lobreglio, Giambattista; Lowies, Cher; Lu, Cheng; Majeed, Haroon; Martin, Adam; Martinez-sobrido, Luis; Meresh, Edwin; Middelveen, Marianne; Mohebbi, Alireza; Mota, Jorge; Mozaheb, Zahra; Muyaya, Ley; Nandhakumar, Amar; Ng, Sheryl H. X.; Obeidat, Monther; Oh, Deog-hwan; Owais, Mohammed; Pace-asciak, Pia; Panwar, Ajay; Park, Caroline; Patterson, Chris; Penagos-tabaree, Felipe; Pianosi, Paolo T.; Pinzi, Valentina; Pridans, Clare; Psaroulaki, Anna; Pujala, Ravi Kumar; Pulido-arjona, Leonardo; Qi, Peng-fei; Rahman, Proton; Rai, Nayanjot K.; Rassaf, Tienush; Refardt, Julie; Ricciardi, Walter; Riess, Olaf; Rovas, Alexandros; Sacks, Frank M.; Saleh, Sherif; Sampson, Christopher; Schmutz, Axel; Sepanski, Robert; Sharma, Neeraj; Singh, Manisha; Spearman, Paul; Subramaniapillai, Mehala; Swali, Ritu; Tan, Cher M.; Tellechea, Juan I.; Thomas, Lisa-marie; Tong, Xin; Veys, Ralf; Vitriol, Veronica; Wang, Horng-dar; Wang, Jinhui; Wang, Jiucun; Waugh, Jason; Webb, S. A.; Williams, Brendan A.; Workman, Alan D.; Xiang, Tingxiu; Xie, Li-xin; Xu, Jun; Xu, Taosheng; Yang, Chongjun; Yoon, Jihoon G.; Yuan, Christina M.; Zaritsky, Arno; Zhang, Yao; Zhao, Haochen; Zuckerman, Hannah; Lyu, Ran; Pullan, Wayne; Zhou, Yaoqi.
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles....
Tipo: Text
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00659/77117/78538.pdf

Phenotypic Response to Light Versus Shade Associated with DNA Methylation Changes in Snapdragon Plants (Antirrhinum majus)
Provedor de dados: 5
Autores: Mouginot, Pierick; Luviano Aparicio, Nelia; Gourcilleau, Delphine; Latutrie, Mathieu; Marin, Sara; Hemptinne, Jean-louis; Grunau, Christoph; Pujol, Benoit.
The phenotypic plasticity of plants in response to change in their light environment, and in particularly, to shade is a schoolbook example of ecologically relevant phenotypic plasticity with evolutionary adaptive implications. Epigenetic variation is known to potentially underlie plant phenotypic plasticity. Yet, little is known about its role in ecologically and evolutionary relevant mechanisms shaping the diversity of plant populations in nature. Here we used a reference-free reduced representation bisulfite sequencing method for non-model organisms (epiGBS) to investigate changes in DNA methylation patterns across the genome in snapdragon plants (Antirrhinum majus L.). We exposed plants to sunlight versus artificially induced shade in four highly...
Tipo: Text
Palavras-chave: Phenotypic plasticity; Epigenetics; EpiGBS; Stem elongation; Shade avoidance.
Ano: 2021
URL: https://archimer.ifremer.fr/doc/00679/79105/81582.pdf

Universality of the DNA methylation codes in Eucaryotes
Provedor de dados: 5
Autores: Aliaga, Benoit; Bulla, Ingo; Mouahid, Gabriel; Duval, David; Grunau, Christoph.
provides just a set of environment dependent instructions, or whether it is integral part of an inheritance system. We argued that in the latter case the epigenetic code should share the universality quality of the genetic code. We focused on DNA methylation. Since availability of DNA methylation data is biased towards model organisms we developed a method that uses kernel density estimations of CpG observed/expected ratios to infer DNA methylation types in any genome. We show here that our method allows for robust prediction of mosaic and full gene body methylation with a PPV of 1 and 0.87, respectively. We used this prediction to complement experimental data, and applied hierarchical clustering to identify methylation types in similar to 150 eucaryotic...
Tipo: Text
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00479/59040/61671.pdf

Environmentally Driven Color Variation in the Pearl Oyster Pinctada margaritifera var. cumingii (Linnaeus, 1758) Is Associated With Differential Methylation of CpGs in Pigment- and Biomineralization-Related Genes
Provedor de dados: 5
Autores: Stenger, Pierre-louis; Ky, Chin-long; Reisser, Celine; Cosseau, Céline; Grunau, Christoph; Mege, Mickael; Planes, Serge; Vidal-dupiol, Jeremie.
Today, it is common knowledge that environmental factors can change the color of many animals. Studies have shown that the molecular mechanisms underlying such modifications could involve epigenetic factors. Since 2013, the pearl oyster Pinctada margaritifera var. cumingii has become a biological model for questions on color expression and variation in Mollusca. A previous study reported color plasticity in response to water depth variation, specifically a general darkening of the nacre color at greater depth. However, the molecular mechanisms behind this plasticity are still unknown. In this paper, we investigate the possible implication of epigenetic factors controlling shell color variation through a depth variation experiment associated with a DNA...
Tipo: Text
Palavras-chave: Pearl oyster; Environmental pressure; Depth; Color change; Pigmentation; DNA methylation; Methylome characterization.
Ano: 2021
URL: https://archimer.ifremer.fr/doc/00685/79667/82436.pdf

The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio)
Provedor de dados: 5
Autores: Blanc, Mélanie; Antczak, Philipp; Cousin, Xavier; Grunau, Christoph; Scherbak, Nikolai; Rüegg, Joëlle; Keiter, Steffen H.
The pyrethroid insecticide permethrin is widely used for agricultural and domestic purposes. Previous data indicated that it acts as a developmental neurotoxicant and can induce transgenerational effects in non-target organisms. However, associated underlying mechanisms remain unclear. The aim of this study was to investigate permethrin-related transgenerational effects in the zebrafish model, and to identify possible molecular mechanisms underlying inheritance. Zebrafish (F0) were exposed to permethrin during early-life (2 h post-fertilization up to 28 days). The F1 and F2 offspring generations were obtained by pairing exposed F0 males and females, and were bred unexposed. Locomotor and anxiety behavior were investigated, together with transcriptomic and...
Tipo: Text
Palavras-chave: Transgenerational epigenetic inheritance; Developmental neurotoxicity; Glutamatergic signaling; DNA methylation; Pesticide.
Ano: 2021
URL: https://archimer.ifremer.fr/doc/00685/79661/82425.pdf

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection
Provedor de dados: 5
Autores: Roquis, David; Lepesant, Julie M. J.; Picard, Marion A. L.; Freitag, Michael; Parrinello, Hugues; Groth, Marco; Emans, Remi; Cosseau, Celine; Grunau, Christoph.
Background Chromatin structure can control gene expression and can define specific transcription states. For example, bivalent methylation of histone H3K4 and H3K27 is linked to poised transcription in vertebrate embryonic stem cells (ESC). It allows them to rapidly engage specific developmental pathways. We reasoned that non-vertebrate metazoans that encounter a similar developmental constraint (i.e. to quickly start development into a new phenotype) might use a similar system. Schistosomes are parasitic platyhelminthes that are characterized by passage through two hosts: a mollusk as intermediate host and humans or rodents as definitive host. During its development, the parasite undergoes drastic changes, most notable immediately after infection of the...
Tipo: Text
Ano: 2015
URL: https://archimer.ifremer.fr/doc/00615/72712/71721.pdf

The Cytoplasm Affects the Epigenome in Drosophila melanogaster
Provedor de dados: 5
Autores: Grunau, Christoph; Voigt, Susanne; Dobler, Ralph; Dowling, Damian K.; Reinhardt, Klaus.
Cytoplasmic components and their interactions with the nuclear genome may mediate patterns of phenotypic expression to form a joint inheritance system. However, proximate mechanisms underpinning these interactions remain elusive. To independently assess nuclear genetic and epigenetic cytoplasmic effects, we created a full-factorial design in which representative cytoplasms and nuclear backgrounds from each of two geographically disjunct populations of Drosophila melanogaster were matched together in all four possible combinations. To capture slowly-accumulating epimutations in addition to immediately occurring ones, these constructed populations were examined one year later. We found the K4 methylation of histone H3, H3K4me3, an epigenetic marker...
Tipo: Text
Palavras-chave: Epigenetics; Mitochondria; Mito-nuclear coevolution; Wolbachia.
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00478/58935/62427.pdf

Measuring Histone Modifications in the Human Parasite Schistosoma mansoni.
Provedor de dados: 5
Autores: De Carvalho Augusto, Ronaldo; Roquis, David; Al Picard, Marion; Chaparro, Christian; Cosseau, Celine; Grunau, Christoph.
DNA-binding proteins play critical roles in many major processes such as development and sexual biology of Schistosoma mansoni and are important for the pathogenesis of schistosomiasis. Chromatin immunoprecipitation (ChIP) experiments followed by sequencing (ChIP-seq) are useful to characterize the association of genomic regions with posttranslational chemical modifications of histone proteins. Challenges in the standard ChIP protocol have motivated recent enhancements in this approach, such as reducing the number of cells required and increasing the resolution. In this chapter, we describe the latest advances made by our group in the ChIP methods to improve the standard ChIP protocol to reduce the number of input cells required and to increase the...
Tipo: Text
Palavras-chave: Native chromatin immunoprecipitation; ChIPmentation; Histone modifications; Schistosomiasis; Trematode; Development.
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00653/76553/77671.pdf

Effects of the Environment on Developmental Plasticity and Infection Success of Schistosoma Parasites - An Epigenetic Perspective
Provedor de dados: 5
Autores: De Carvalho Augusto, Ronaldo; Duval, David; Grunau, Christoph.
Evidence of how environmental cues affect the phenotypes of, and compatibility between Schistosoma mansoni and their hosts come from studies in environmental parasitology and research on host diet and chemotherapeutic treatment. Schistosomes deal with a multitude of signals from the water environment as well as cues that come from their hosts, particularly in response to molecules that serve to recognize and destroy them, i.e., those molecules that arise from their hosts' immune systems. These interactions shape, not only the parasite's morphology, metabolism and behavior in the short-term, but also their infection success and development into different stage-specific phenotypes later in their life cycle, through the modification of the parasite's...
Tipo: Text
Palavras-chave: Schistosomiasis; Environmental cues; Inheritance systems; Imune response; Host-para site interactions.
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00508/61941/66028.pdf

Epigenetic origin of adaptive phenotypic variants in the human blood fluke Schistosoma mansoni
Provedor de dados: 5
Autores: Fneich, Sara; Theron, Andre; Cosseau, Celine; Rognon, Anne; Aliaga, Benoit; Buard, Jerome; Duval, David; Arancibia, Nathalie; Boissier, Jerome; Roquis, David; Mitta, Guillaume; Grunau, Christoph.
Background: Adaptive evolution is not possible without the generation of phenotypic variants. The origin of these variations has been a central topic in evolutionary biology. Up to now, it was commonly accepted that standing genetic variation is the only cause of phenotypic variants. However, epigenetic information is emerging as a complementary source of heritable phenotypic variation that contributes to evolution. The relative importance of genetics and epigenetics in generating heritable phenotypic variation is nevertheless a matter of debate. Results: We used a host-parasite system to address this question. The human blood fluke Schistosoma mansoni can adapt rapidly to new intermediate snail hosts. The interaction between parasite and mollusk is...
Tipo: Text
Palavras-chave: Epigenetics; Adaptive evolution; Compatibility polymorphism; Schistosoma mansoni.
Ano: 2016
URL: https://archimer.ifremer.fr/doc/00615/72708/71730.pdf

Effects of a parental exposure to diuron on Pacific oyster spat methylome
Provedor de dados: 5
Autores: Rondon Sallan, Rodolfo; Grunau, Christoph; Fallet, Manon; Charlemagne, Nicolas; Sussarellu, Rossana; Chaparro, Cristian; Montagnani, Caroline; Mitta, Guillaume; Bachere, Evelyne; Akcha, Farida; Cosseau, Celine.
Environmental epigenetic is an emerging field that studies the cause-effect relationship between environmental factors and heritable trait via an alteration in epigenetic marks. This field has received much attentions since the impact of environmental factors on different epigenetic marks have been shown to be associated with a broad range of phenotypic disorders in natural ecosystems. Chemical pollutants have been shown to affect immediate epigenetic information carriers of several aquatic species but the heritability of the chromatin marks and the consequences for long term adaptation remain open questions. In this work, we investigated the impact of the diuron herbicide on the DNA methylation pattern of spat from exposed Crassotrea gigas genitors. This...
Tipo: Text
Palavras-chave: Crassostrea gigas; Mollusk; DNA methylation; Herbicide; Epigenetic.
Ano: 2017
URL: https://archimer.ifremer.fr/doc/00602/71413/69895.pdf

Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites
Provedor de dados: 5
Autores: Augusto, Ronaldo De Carvalho; Tetreau, Guillaume; Chan, Philippe; Walet-balieu, Marie-laure; Mello-silva, Clelia Christina; Santos, Claudia Portes; Grunau, Christoph.
Background Schistosomiasis has been reported in 78 endemic countries and affects 240 million people worldwide. The digenetic parasite Schistosoma mansoni needs fresh water to compete its life cycle. There, it is susceptible to soluble compounds that can affect directly and/or indirectly the parasite's biology. The cercariae stage is one of the key points in which the parasite is vulnerable to different soluble compounds that can significantly alter the parasite's life cycle. Molluscicides are recommended by the World Health Organization for the control of schistosomiasis transmission and Euphorbia milii latex is effective against snails intermediate hosts. Methodology/Principal findings We used parasitological tools and electron microscopy to verify the...
Tipo: Text
Ano: 2017
URL: https://archimer.ifremer.fr/doc/00398/50960/71803.tif

A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni
Provedor de dados: 5
Autores: Galinier, Richard; Roger, Emmanuel; Mone, Yves; Duval, David; Portet, Anais; Pinaud, Silvain; Chaparro, Cristian; Grunau, Christoph; Genthon, Clemence; Dubois, Emeric; Rognon, Anne; Arancibia, Nathalie; Dejean, Bernard; Theron, Andre; Gourbal, Benjamin; Mitta, Guillaume.
In recent decades, numerous studies have sought to better understand the mechanisms underlying the compatibility between Biomphalaria glabrata and Schistosoma mansoni. The developments of comparative transcriptomics, comparative genomics, interactomics and more targeted approaches have enabled researchers to identify a series of candidate genes. However, no molecular comparative work has yet been performed on multiple populations displaying different levels of compatibility. Here, we seek to fill this gap in the literature. We focused on B. glabrata FREPs and S. mansoni SmPoMucs, which were previously demonstrated to be involved in snail/schistosome compatibility. We studied the expression and polymorphisms of these factors in combinations of snail and...
Tipo: Text
Ano: 2017
URL: https://archimer.ifremer.fr/doc/00388/49951/50515.pdf

Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation
Provedor de dados: 5
Autores: Picard, Marion A. L.; Boissier, Jerome; Roquis, David; Grunau, Christoph; Allienne, Jean-francois; Duval, David; Toulza, Eve; Arancibia, Nathalie; Caffrey, Conor R.; Long, Thavy; Nidelet, Sabine; Rohmer, Marine; Cosseau, Celine.
Background Among more than 20,000 species of hermaphroditic trematodes, Schistosomatidae are unusual since they have evolved gonochorism. In schistosomes, sex is determined by a female heterogametic system, but phenotypic sexual dimorphism appears only after infection of the vertebrate definitive host. The completion of gonad maturation occurs even later, after pairing. To date, the molecular mechanisms that trigger the sexual differentiation in these species remain unknown, and in vivo studies on the developing schistosomulum stages are lacking. To study the molecular basis of sex determination and sexual differentiation in schistosomes, we investigated the whole transcriptome of the human parasite Schistosoma mansoni in a stage-and sex-comparative...
Tipo: Text
Ano: 2016
URL: https://archimer.ifremer.fr/doc/00358/46876/71864.pdf