Consulta: creatorFacets:"Gutierrez,P.S."
Registros recuperados: 2
Data/hora: 11/06/2024 07:15:46

Coronary fat content evaluated by morphometry in patients with severe atherosclerosis has no relation with serum lipid levels
Provedor de dados: 56
Autores: Braz Jr.,D.J.; Gutierrez,P.S.; Luz,P.L. da.
The relationship between lipid serum levels and coronary atherosclerotic plaque fat content was studied in 51 necropsy patients. Serum lipids were measured by standard techniques, during life, in the absence of lipid-lowering drugs. Intima, intimal fat and media areas were measured using a computerized system in cryosections of the odd segments of the right, anterior descending and circumflex coronary arteries stained with Sudan-IV. Mean intimal and lipid areas were 5.74 ± 1.98 and 1.22 ± 0.55 mm² (22.12 ± 8.48%) in 26 cases with high cholesterol (³200 mg/dL) and 4.98 ± 1.94 and 1.16 ± 0.66 mm² (22.75 ± 9.06%) in 25 cases with normal cholesterol (&lt;200 mg/dL; P &gt; 0.05). Patients with high levels of low-density lipoprotein (³130 mg/dL, N = 15) had a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coronary arteriosclerosis; Cholesterol; Image cytometry.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400004

Methotrexate associated to lipid core nanoparticles improves cardiac allograft vasculopathy and the inflammatory profile in a rabbit heart graft model
Provedor de dados: 56
Autores: Fiorelli,A.I.; Lourenço-Filho,D.D.; Tavares,E.R.; Carvalho,P.O.; Marques,A.F.; Gutierrez,P.S.; Maranhão,R.C.; Stolf,N.A.G.
Coronary allograft vasculopathy is an inflammatory-proliferative process that compromises the long-term success of heart transplantation and has no effective treatment. A lipid nanoemulsion (LDE) can carry chemotherapeutic agents in the circulation and concentrates them in the heart graft. The aim of the study was to investigate the effects of methotrexate (MTX) associated to LDE. Rabbits fed a 0.5% cholesterol diet and submitted to heterotopic heart transplantation were treated with cyclosporine A (10 mg·kg–1·day–1 orally) and allocated to treatment with intravenous LDE-MTX (4 mg/kg, weekly, n=10) or with weekly intravenous saline solution (control group, n=10), beginning on the day of surgery. Animals were euthanized 6 weeks later. Compared to controls,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nanoemulsions; Solid lipid particles; Methotrexate; Inflammatory mediators; LDL receptors.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001000608