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Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis
Provedor de dados: 56
Autores: Hou,Yun; Wang,Xi Feng; Lang,Zhi Qiang; Jin,Yin Chuan; Fu,Jia Rong; Xv,Xiao Min; Sun,Shi Tian; Xin,Xin; Zhang,Lian Shuang.
Endoplasmic reticulum (ER) stress is a critical molecular mechanism involved in the pathogenesis of sepsis. Hence, strategies for alleviating this stress may be essential for preventing cardiovascular injuries under sepsis. Adiponectin is secreted by adipocytes and its levels are decreased in sepsis. The purpose of this study was to investigate the protective effects of adiponectin treatment on endothelial cells and its mechanism. Male Wistar rats underwent cecal ligation and puncture (CLP) before being treated with adiponectin (72 and 120 μg/kg). The levels of malondialdehyde (MDA) in plasma, histological structure, and apoptosis of endothelial cells were evaluated. In vitro, human umbilical vein endothelial cells (HUVECs) were treated with adiponectin at...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adiponectin; Apoptosis; Endoplasmic reticulum stress; Endothelial cell; Sepsis.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200609