Consulta: creatorFacets:"Huclier-markai, Sandrine"
Registros recuperados: 2
Data/hora: 09/06/2024 09:35:48

Antiproliferative Properties of Scandium Exopolysaccharide Complexes on Several Cancer Cell Lines
Provedor de dados: 5
Autores: Muñoz-garcia, Javier; Mazza, Mattia; Alliot, Cyrille; Sinquin, Corinne; Colliec-jouault, Sylvia; Heymann, Dominique; Huclier-markai, Sandrine.
Antimetastatic properties on both murine and human osteosarcoma cell lines (POS-1 and KHOS) have been evidenced using exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium. These derivatives had no significant effect on the cell cycle neither a pro-apoptotic effect on osteosarcoma cells. Based on this observation, these EPSs could be employed as new drug delivery systems for therapeutic uses. A theranostic approach, i.e., combination of a predictive biomarker with a therapeutic agent, has been developed notably by combining with true pair of theranostic radionuclides, such as scandium 47Sc/44Sc. However, it is crucial to ensure that, once complexation is done, the biological properties of the vector remain intact, allowing the...
Tipo: Text
Palavras-chave: Exopolysaccharides; Scandium; Theranostic; Cancer cell lines; Proliferation.
Ano: 2021
URL: https://archimer.ifremer.fr/doc/00686/79826/82630.pdf

Marine Exopolysaccharide Complexed with Scandium Aimed as Theranostic Agents
Provedor de dados: 5
Autores: Mazza, Mattia; Alliot, Cyrille; Sinquin, Corinne; Colliec-jouault, Sylvia; Reiller, Pascal E.; Huclier-markai, Sandrine.
Background: Exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium, showed anti-metastatic properties. They may represent a new class of ligands to be combined with theranostic radionuclides, such as 47Sc/44Sc. The goal of this work was to investigate the feasibility of such coupling. (2) Methods: EPSs, as well as heparin used as a drug reference, were characterized in terms of molar mass and dispersity using Asymmetrical Flow Field-Flow Fractionation coupled to Multi-Angle Light Scattering (AF4-MALS). The intrinsic viscosity of EPSs at different ionic strengths were measured in order to establish the conformation. To determine the stability constants of Sc with EPS and heparin, a Free-ion selective radiotracer extraction (FISRE)...
Tipo: Text
Palavras-chave: Exopolysaccharides; Scandium; Theranostic; Characterization; Complexation.
Ano: 2021
URL: https://archimer.ifremer.fr/doc/00681/79332/81844.pdf