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Effects of bromopride on expression of metalloproteinases and interleukins in left colonic anastomoses: an experimental study
Provedor de dados: 56
Autores: Silva,S.M.; Jerônimo,M.S.; Silva-Pereira,I.; Bocca,A.L.; Sousa,J.B.
Anastomotic dehiscence is the most severe complication of colorectal surgery. Metalloproteinases (MMPs) and interleukins (ILs) can be used to analyze the healing process of anastomosis. To evaluate the effects of bromopride on MMP and cytokine gene expression in left colonic anastomoses in rats with or without induced abdominal sepsis, 80 rats were divided into two groups for euthanasia on the third or seventh postoperative day (POD). They were then divided into subgroups of 20 rats for sepsis induction or not, and then into subgroups of 10 rats for administration of bromopride or saline. Left colonic anastomosis was performed and abdominal sepsis was induced by cecal ligation and puncture. A colonic segment containing the anastomosis was removed for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bromopride; Matrix metalloproteinases; Interleukins; Surgical anastomosis; Sepsis; Rats.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001000911